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  • Experimental Eosinophilia with an Extract of an Animal Parasite. Its Relation to Anaphylaxis and certain Clinical Problems.

    Author(s) : HERRICK, W. W.

    Journal article : Archives of Internal Medicine 1913 Vol.11 No.2 pp.165-186

    Abstract : The functions of the eosinophile cells remain one of the mysteries of biology and little is known of the role they play in the economy of the body. The problems towards which the author directed his attention were as follows: -
    " 1. Whether eosinophilia of the blood could be produced experimentally by the use of an extract of Ascaris lumbricoides. 2. Under what conditions of administration of this extract such eosinophilia might be brought about. 3. Whether or not the substance influencing the eosinophils is a protein. 4. Whether such eosinophil increase bears any relation to specific sensitization or anaphylaxis." Throughout the work the possible relationship of these questions to the clinical problem of bronchial asthma was also kept constantly in mind.
    After a long series of experiments with guineapigs and numerous blood examinations, the author has reached the following conclusions: -
    " 1. A notable eosinophilia of the blood can be developed by the intro-peritoneal injection of an aqueous extract of Ascaris lumbricoides.
    " 2. The substance causing such eosinophil increase is a protein.
    " 3. Previous sensitization is necessary to the development of this eosinophilia.
    " 4. It is impossible to produce such eosinophilia while the animals are immune to the extract.
    " 5. This eosinophilia may therefore be considered evidence of previous sensitization.
    " 6. There is a possible association of these facts with the problem of bronchial asthma."
    G. C. L.

    ISSN : 0003-9926

    DOI : 10.1001/archinte.1913.00060260046003

    Record Number : 19122900876

    Language of text : not specified

    Language of summary : not specified