DOBELL, C.; Low, G. C.
The authors investigated a single case of infection with Lamblia mtesli'nolis. The subject was a carrier, being apparently healthy, and no other Protozoon infection was found in him. Before treatment his stools were examined daily for 100 days. On certain days parasites were present while on others they were absent, but no periodicity in the number of cysts voided was determined. [But only coverglass preparations were examined, and measured quantities of faeces were not used.] The supposed efficacy of various drugs was then tested. Bismuth salicylate 20 gr. and beta-naphthol 15 gr., made up in cachets, were given three times daily after food, the administration being continued for six days. The cysts disappeared during treatment and for six days afterwards, but then reappeared in the stools.
The action of méthylène blue was next tried. Three grains of the zinc-free drug were administered thrice daily after food. The treatment was only able to be continued for two days owing to the appearance of toxic symptoms, chiefly manifested as bladder irritation. The drug appeared to have no effect. A turpentine mixture was then tried. 10 minims in gelatine capsules were given three times daily for five days, followed by guaiacol carbonate 5 gr. thrice daily for three days. However, the cysts did not disappear.
The authors have also examined other cases treated with various drugs, such as emetine hydrochloride, emetine bismuth iodide, bismuth subnitrate, thymol, salol, kerol, cylîin and liquid paraffin. These drugs did not appear to have had any effect on the parasite. The authors show the need for the daily examination of stools before, during, and for some time after treatment. The blood of the subject was also examined, and blood counts were made. The number of red corpuscles, white corpuscles and the differential leukocyte count were normal, while the haemoglobin was 100 per cent.
In conclusion, the authors rightly state that they do not wish to draw any far-reaching conclusions from the single case described. [The need for daily examinations of the faeces of Lamblia-infected patients and the occurrence of daily variations in the numbers of the parasites have already been emphasised bv PORTER-see this Bulletin. vol. 8, p. 131-2.] A. P.
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