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  • Growth Requirements of Dysgonic and Eugonic Strains of Mycobacterium tuberculosis var. bovis.

    Author(s) : SCHAEFER, W. B.

    Journal article : Journal of Experimental Medicine 1952 Vol.96 No.3 pp.207-19 ref.15

    Abstract : The growthgrowthSubject Category: Natural Processes
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    of 10 bovine, 3 human and 5 BCG strainsstrainsSubject Category: Organism Groups
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    of tubercle bacilli in a modified Tween-80-albumin liquid medium, containing ammonium chlorideammonium chlorideSubject Category: Chemicals and Chemical Groups
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    or glutamate as the source of N, was measured with a photometer.
    Dysgonic bovine strains required for multiplication long-chain fatty acidsfatty acidsSubject Category: Chemicals and Chemical Groups
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    which could be supplied as Tween 80 or oleic, palmitic or stearic acids. In the presence of these acids the growth of the strains was increased by adding small amounts of glucose or glycerol, whereas larger amounts inhibited growth, ín glucose-fatty-acid media the growth was further stimulated by adding glutamate, succinate, malate or acetate. Pyruvate enabled dysgonic strains to grow rapidly in media with glucose but without fatty acid. The author suggests that essential metabolites of tubercle bacilli may be formed either from glucose or glycerol via pyruvate, or from fatty acids. In dysgonic strains the conversion of glucose or glycerol to pyruvate may be deficient.
    With eugonic strains growth was slightly stimulated by fatty acids but was not dependent on their presence; it was also stimulated by large amounts of glucose or glycerol. It is suggested that the conversion of glucose or glycerol to pyruvate is an important step in the formation of the metabolites of eugonic strains. D. A. Mitchison.

    ISSN : 0022-1007

    DOI : 10.1084/jem.96.3.207

    Record Number : 19532703093

    Language of text : not specified

    Language of summary : not specified

    Indexing terms for this abstract:

    Organism descriptor(s) : manmanSubject Category: Organism Names
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    , MycobacteriummycobacteriumSubject Category: Organism Names
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    , Mycobacterium tuberculosismycobacterium tuberculosisSubject Category: Organism Names
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    Descriptor(s) : ammonium chlorideammonium chlorideSubject Category: Chemicals and Chemical Groups
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    , BCG vaccinebcg vaccineSubject Category: Commodities and Products
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    , culture mediaculture mediaSubject Category: Miscellaneous
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    , fatty acidsfatty acidsSubject Category: Chemicals and Chemical Groups
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    , growthgrowthSubject Category: Natural Processes
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    , pyruvic acidpyruvic acidSubject Category: Chemicals and Chemical Groups
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    , strainsstrainsSubject Category: Organism Groups
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    , tuberculosistuberculosisSubject Category: Diseases, Disorders, and Symptoms
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    , vaccinesvaccinesSubject Category: Commodities and Products
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    Identifier(s) : ammonium hydrochloride, bacterium, pyruvate

    Broader term(s) : HomohomoSubject Category: Organism Names
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    , HominidaehominidaeSubject Category: Organism Names
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    , primatesprimatesSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , MycobacteriaceaemycobacteriaceaeSubject Category: Organism Names
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    , CorynebacterineaecorynebacterineaeSubject Category: Organism Names
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    , ActinomycetalesactinomycetalesSubject Category: Organism Names
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    , ActinobacteridaeactinobacteridaeSubject Category: Organism Names
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    , ActinobacteriaactinobacteriaSubject Category: Organism Names
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    , BacteriabacteriaSubject Category: Organism Names
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    , prokaryotesprokaryotesSubject Category: Organism Names
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    , MycobacteriummycobacteriumSubject Category: Organism Names
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