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  • Production of hypercholesterolemia and atherosclerosis in rabbits by feeding different fats without supplementary cholesterol.

    Author(s) : WIGAND, G.

    Author Affiliation : Dept. Med., Univ. Lund.

    Journal article : Acta Medica Scandinavica 1960 Vol.166 No.351 pp.91 pp.

    Abstract : The rabbitsrabbitsSubject Category: Organism Names
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    used were adult and for at least a month had been freely fed on green roughageroughageSubject Category: Commodities and Products
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    and crushed barleybarleySubject Category: Commodities and Products
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    . The basal dietdietSubject Category: Miscellaneous
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    was of, per cent., purified caseincaseinSubject Category: Chemicals and Chemical Groups
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    25.26, sucrosesucroseSubject Category: Chemicals and Chemical Groups
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    5.51, glucose 6.73, wheatwheatSubject Category: Commodities and Products
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    starchstarchSubject Category: Chemicals and Chemical Groups
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    16.83, fat 8.42, cellulose 18.94, salt mixture 4.89, choline chloride 0.25, inositol 0.34, talc 3.37, colloidal silicic acid (Aerosil) 6.31 and vitaminsvitaminsSubject Category: Chemicals and Chemical Groups
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    . The fat was butterbutterSubject Category: Commodities and Products
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    , hydrogenated coconut oilcoconut oilSubject Category: Commodities and Products
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    , maize oilmaize oilSubject Category: Commodities and Products
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    , rapeseed oilrapeseed oilSubject Category: Commodities and Products
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    , or glyceryl trilaurate alone or with linoleic acidlinoleic acidSubject Category: Chemicals and Chemical Groups
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    or maize oil. The dietsdietsSubject Category: Miscellaneous
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    were prepared as pelletspelletsSubject Category: Commodities and Products
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    . The control group received green roughage and barley except towards the end when the roughage was hayhaySubject Category: Commodities and Products
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    and roots. The diets were given for 18 weeks, except those with hydrogenated coconut oil and maize oil, which were given for 15 weeks. Intake was restricted to 25 g. daily of the experimental diets and animalsanimalsSubject Category: Organism Names
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    were paired so that if one did not eat all its foodfoodSubject Category: Commodities and Products
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    its partners in other groups had a reduced allowance the next day. Serum cholesterolcholesterolSubject Category: Chemicals and Chemical Groups
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    was estimated every 3 weeks.
    The diets with butterfat, maize oil or rapeseed oil gave a moderate gain of weight, but on those with coconut oil or glyceryl trilaurate weight was not gained or was lost. On the diet of greens and barley serum cholesterol continued at its initial level of between 25 and 58 mg. per 100 ml. With maize oil or rapeseed oil there was a slight increase in the first few weeks and then more or less steady values, with final means of 69 and 72 mg. per 100 ml. ; the increase was small although significant and very few values exceeded 140 mg. per 100 ml. With butterfat serum cholesterol in most rabbits began to rise between the 3rd and the 6th week and at the end only one value was below 150 mg. per 100 ml., with a mean of 358 and a peak of 733. Values fluctuated in each animal but the mean rose steadily. Even greater increases were produced by hydrogenated coconut oil; the rise began at about the same time as with butter and the final mean was 558, with a peak value of 1420 mg. per 100 ml. The difference from the group given butter was significant. In 3 rabbits which had the pellets with coconut oil for 54 weeks the increase persisted. In 2 rabbits switched from coconut to maize oil after 21 weeks serum cholesterol fell rapidly from 787 and 1855 to about 250 mg. and then declined more slowly to normal. Glyceryl trilaurate gave a rise of serum cholesterol, which in the 4 rabbits reached from 742 to 1343 mg. after 12 to 15 weeks but then declined somewhat to a mean of 665 after 18 weeks. The rise was slower and less when 4 per cent. linoleic acid was given with 8 per cent. glyceryl trilaurate, and 4 per cent. maize oil seemed even more effective, but there were only 2 rabbits in each group and results were not treated statistically.
    When serum lipids were examined in more detail it was found that the rise of serum total cholesterol when butter was given was mainly in the ester fraction, but that caused by hydrogenated coconut oil or glyceryl trilaurate was equally in the free and bound fractions. Serum triglyceride was not affected by butter but was increased by coconut oil or glyceryl trilaurate and reduced by maize oil or rapeseed oil. Serum phospholipid was increased by the fatsfatsSubject Category: Chemicals and Chemical Groups
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    which increased cholesterol, but the cholesterol: phospholipid ratio rose in all groups. The fats which increased cholesterol also increased total lipids and β + 0-lipoproteins.
    Hydrogenated coconut oil, butter and glyceryl trilaurate produced increasing loss of hair but no other skin lesion. The aortaaortaSubject Category: Anatomical and Morphological Structures
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    appeared grossly normal in rabbits on roughage diet or given maize oil or rapeseed oil, but butter or hydrogenated coconut oil produced atherosclerosisatherosclerosisSubject Category: Diseases, Disorders, and Symptoms
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    in about 9 out of 10 rabbits. Glyceryl trilaurate alone caused similar changes in all 4 rabbits, so did glyceryl trilaurate with linoleic acid in 2 rabbits, but maize oil appeared to have prevented atherosclerosis. Significant positive correlation was found between cholesterol levels and cholesterol: phospholipid ratiosratiosSubject Category: Properties
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    in serum and the incidence and severity of atherosclerosis.-D. Duncan.

    ISSN : 0001-6101

    Record Number : 19601406001

    Language of text : not specified

    Language of summary : not specified

    Indexing terms for this abstract:

    Organism descriptor(s) : Hordeum vulgarehordeum vulgareSubject Category: Organism Names
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    , rabbitsrabbitsSubject Category: Organism Names
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    , TriticumtriticumSubject Category: Organism Names
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    , Zea mayszea maysSubject Category: Organism Names
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    Descriptor(s) : aortaaortaSubject Category: Anatomical and Morphological Structures
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    , arteriesarteriesSubject Category: Anatomical and Morphological Structures
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    , atherosclerosisatherosclerosisSubject Category: Diseases, Disorders, and Symptoms
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    , barleybarleySubject Category: Commodities and Products
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    , blood chemistryblood chemistrySubject Category: Miscellaneous
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    , blood lipidsblood lipidsSubject Category: Chemicals and Chemical Groups
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    , blood serumblood serumSubject Category: Anatomical and Morphological Structures
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    , butterbutterSubject Category: Commodities and Products
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    , caseincaseinSubject Category: Chemicals and Chemical Groups
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    , cholesterolcholesterolSubject Category: Chemicals and Chemical Groups
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    , coconut oilcoconut oilSubject Category: Commodities and Products
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    , dietdietSubject Category: Miscellaneous
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    , dietsdietsSubject Category: Miscellaneous
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    , fatsfatsSubject Category: Chemicals and Chemical Groups
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    , feedingfeedingSubject Category: Techniques, Methodologies and Equipment
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    , feedsfeedsSubject Category: Commodities and Products
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    , foodfoodSubject Category: Commodities and Products
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    , forageforageSubject Category: Miscellaneous
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    , hayhaySubject Category: Commodities and Products
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    , hypercholesterolaemiahypercholesterolaemiaSubject Category: Diseases, Disorders, and Symptoms
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    , lesionslesionsSubject Category: Diseases, Disorders, and Symptoms
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    , linoleic acidlinoleic acidSubject Category: Chemicals and Chemical Groups
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    , lipidslipidsSubject Category: Chemicals and Chemical Groups
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    , maizemaizeSubject Category: Commodities and Products
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    , maize oilmaize oilSubject Category: Commodities and Products
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    , milk fatmilk fatSubject Category: Commodities and Products
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    , milk productsmilk productsSubject Category: Commodities and Products
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    , milksmilksSubject Category: Miscellaneous
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    , myo-inositolmyo-inositolSubject Category: Chemicals and Chemical Groups
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    , pelletspelletsSubject Category: Commodities and Products
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    , phospholipidsphospholipidsSubject Category: Chemicals and Chemical Groups
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    , polyenoic fatty acidspolyenoic fatty acidsSubject Category: Chemicals and Chemical Groups
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    , rapeseedrapeseedSubject Category: Commodities and Products
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    , rapeseed oilrapeseed oilSubject Category: Commodities and Products
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    , ratiosratiosSubject Category: Properties
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    , roughageroughageSubject Category: Commodities and Products
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    , starchstarchSubject Category: Chemicals and Chemical Groups
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    , sucrosesucroseSubject Category: Chemicals and Chemical Groups
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    , vitaminsvitaminsSubject Category: Chemicals and Chemical Groups
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    , wheatwheatSubject Category: Commodities and Products
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    , lipid metabolism disorderslipid metabolism disordersSubject Category: Diseases, Disorders, and Symptoms
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    Identifier(s) : arteriosclerosis, butterfat, canola oil, corn, corn oil, dairy products, dyslipidaemia, dyslipidemia, fat metabolism disorders, feeding stuffs, hypercholesterinemia, hypercholesterolemiahypercholesterolemiaSubject Category: Diseases, Disorders, and Symptoms
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    , inositol, lipins, meso-inositol, polyunsaturated fatty acids, saccharose

    Broader term(s) : HordeumhordeumSubject Category: Organism Names
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    , PoaceaepoaceaeSubject Category: Organism Names
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    , PoalespoalesSubject Category: Organism Names
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    , commelinidscommelinidsSubject Category: Organism Names
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    , monocotyledonsmonocotyledonsSubject Category: Organism Names
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    , angiospermsangiospermsSubject Category: Organism Names
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    , SpermatophytaspermatophytaSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , LeporidaeleporidaeSubject Category: Organism Names
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    , LagomorphalagomorphaSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , ZeazeaSubject Category: Organism Names
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