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  • ECG scoring system for the early detection of digoxin or digitalis poisoning.

    Foreign Title : Ein EKG-Punktsystem zur Erkennung von Digoxin- bzw. Digitalisintoxikationen.

    Author(s) : Detweiler, D. K.Trautvetter, E.

    Author Affiliation : Kleintierklinik, Oertzenweg 19 b, D-1000 Berlin 37, German Federal Republic.

    Journal article : Berliner und Münchener Tierärztliche Wochenschrift Vol.93 No.21 pp.424-426 ref.18

    Abstract : DigoxindigoxinSubject Category: Chemicals and Chemical Groups
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    intoxication was produced by i/v injection with 0.125 mg/kg on the first day in 3 doses. When no signs of intoxication were observed on the second day a further 0.025 mg/kg was administered with none on the third day. When intoxication was observed no digoxin was given, but a further 0.015 mg/kg was injected on the third day. ECG readings were taken twice daily. The most important ECG changes associated with digoxin poisoning were: T-wave flattening in the V10 lead, arterioventricular block, T-wave reversal in the precardial lead, sinus bradycardia. Other signs included paroxysmal atrial tachycardia with or without block, T-wave reversal in the V10 lead, sinus tachycardia, atrial extrasystole. A points system ranging from 0 (no signs of intoxication) to 5 (3 definite signs of digoxin poisoning) was developed, with three grades of severity of intoxication, I, none-slight, 0-3 points, II, moderate, 2-4 points, III, severe, 3-5. Serum digoxin levels were: none-slight, 0-2.5 ng/ml; moderate and severe, 6 ng/ml and above. With slight poisoning no clinical symptoms were observed. With moderate to severe, food intake decreased 50-100%, water intake 10-90%, dogsdogsSubject Category: Organism Names
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    were apathetic and started to vomit, body temperature fell 0.5-1.5 deg C, blood urea and creatinine increased several-fold, Na and Cl decreased and K increased. Epicardial haemorrhages occurred in the right atrium, subendocardial haemorrhages in the left ventricle. Intramural coronary arteritis and myocardial degeneration and necroses were observed. It is suggested that this scoring system can be used in clinical cases as an early warning of digitalis intoxication when serum digoxin levels cannot be measured.

    ISSN : 0005-9366

    Record Number : 19802262507

    Language of text : German

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : DOGSdogsSubject Category: Organism Names
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    Descriptor(s) : cardiac glycosidescardiac glycosidesSubject Category: Chemicals and Chemical Groups
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    , Cardiovascular systemcardiovascular systemSubject Category: Anatomical and Morphological Structures
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    , DiagnosisdiagnosisSubject Category: Techniques, Methodologies and Equipment
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    , digoxindigoxinSubject Category: Chemicals and Chemical Groups
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    , drug toxicitydrug toxicitySubject Category: Properties
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    , ELECTROCARDIOGRAMSelectrocardiogramsSubject Category: Techniques, Methodologies and Equipment
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    , Heart diseasesheart diseasesSubject Category: Diseases, Disorders, and Symptoms
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    Identifier(s) : circulatory system, coronary diseases, digoxin poisoning, ECG

    Broader term(s) : CaniscanisSubject Category: Organism Names
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    , CanidaecanidaeSubject Category: Organism Names
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    , FissipedafissipedaSubject Category: Organism Names
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    , carnivorescarnivoresSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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