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  • Ontogeny of pig discrete Peyer's patches: distribution and morphometric analysis.

    Author(s) : Makala, L. H. C.Kamada, T.Nishikawa, Y.Nagasawa, H.Igarashi, I.Fujisaki, K.Suzuki, N.Mikami, T.Haverson, K.Bailey, M.Stokes, C. R.Bland, P. W.

    Author Affiliation : National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan.

    Author Email : nrcpmi@obihiro.ac.jp

    Journal article : Pathobiology 2000 Vol.68 No.6 pp.275-282 ref.49

    Abstract : We investigated the development of lymphoid and non-lymphoid cells in discrete Peyer's patches (PP) of the pig using immuno-histology and image analysis. In newborn piglets, discrete PP were mainly populated by CD2+, CD3+ T cells, and major histocompatibility complex class II+ cells, many of which were of macrophage and dendritic cell lineage. Four days after birth, cells were localized in defined regions: the follicle; the inter-follicular area and the dome region. Compartmentalization within the follicle started about 6 days after birth. The first signs of secondary follicles were seen from about 14 days. The pig discrete PP attained their mature structure at about 3 weeks after birth. Here, we show that despite the demonstration at birth of the cell types that support antigen processing and presentation, PP did not fully differentiate morphologically until at least this time when antigen can be handled in an efficient manner.

    ISSN : 1015-2008

    DOI : 10.1159/000055938

    Record Number : 20023078505

    Publisher : S Karger AG

    Location of publication : Basel

    Country of publication : Switzerland

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : pigspigsSubject Category: Organism Names
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    Descriptor(s) : morphogenesismorphogenesisSubject Category: Miscellaneous
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    , morphometricsmorphometricsSubject Category: Techniques, Methodologies and Equipment
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    , ontogenyontogenySubject Category: Miscellaneous
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    , peyer patchespeyer patchesSubject Category: Anatomical and Morphological Structures
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    , T lymphocytest lymphocytesSubject Category: Anatomical and Morphological Structures
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    Identifier(s) : developmental biology, hogs, ontogenesis, swine, T cells

    Broader term(s) : Sus scrofasus scrofaSubject Category: Organism Names
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    , SussusSubject Category: Organism Names
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    , SuidaesuidaeSubject Category: Organism Names
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    , SuiformessuiformesSubject Category: Organism Names
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    , ArtiodactylaartiodactylaSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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