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  • Cytotoxicity studies of Eurycoma longifolia extracts against a panel of human cancer cell lines.

    Author(s) : Nurhanan, M. Y.Azimahtol, H. L. P.Azizol, A. K.

    Author Affiliation : Medicinal Plant Division, Forest Research Institute Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, Malaysia.

    Author Email : hanan@frim.gov.my

    Editors : Chang YuShyunMohtar, M.Subramaniam, V.Yunos, N. M.

    Book chapter; Conference paper : Towards modernisation of research and technology in herbal industries. Proceedings of the Seminar on Medicinal and Aromatic Plants, 24-25 July 2001 2002 pp.124-127 ref.4

    Conference Title : Towards modernisation of research and technology in herbal industries. Proceedings of the Seminar on Medicinal and Aromatic Plants, 24-25 July 2001.

    Abstract : E. longifolia (Tongkat Ali) is a species in the family SimaroubaceaesimaroubaceaeSubject Category: Organism Names
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    that has a characteristic bitter taste. Extracts from E. longifolia rootsrootsSubject Category: Anatomical and Morphological Structures
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    collected from MalaysiamalaysiaSubject Category: Geographic Entities
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    were obtained through a successive extraction procedure. The cytotoxicitycytotoxicitySubject Category: Properties
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    studies were carried out on the crude extracts as well as the partitioning products against a panel of human cancer cell linescell linesSubject Category: Organism Groups
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    with the methylene blue bioassay. The cell lines tested were prostateprostateSubject Category: Anatomical and Morphological Structures
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    tumour (DU-145), pelvic (RD) epidermoid carcinomacarcinomaSubject Category: Diseases, Disorders, and Symptoms
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    (KB) and normal Chang's liverliverSubject Category: Anatomical and Morphological Structures
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    . Methanolic (ME) extract showed a significant cytotoxic effect (IC50≤20.0 µg/ml) against RD and KB, however, it did not show any significant cytotoxic effect against DU-145 (IC50=33.0 mg/ml). Petroleum ether and aqueous extracts showed insignificant cytotoxic effect (IC50>20.0 µg/ml) against all the cancer cell lines tested. No toxic effect was observed for these extracts when treated on the normal Chang's liver cell line. These findings suggested that E. longifolia extract particularly ME might contain some active phytochemicalsphytochemicalsSubject Category: Commodities and Products
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    phytochemicalsSubject Category: Chemicals and Chemical Groups
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    that have antineoplastic propertiesantineoplastic propertiesSubject Category: Properties
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    .

    ISBN : 9832181321

    Record Number : 20033046907

    Publisher : Forest Research Institute Malaysia (FRIM)

    Location of publication : Kuala Lumpur

    Country of publication : Malaysia

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Eurycoma longifoliaeurycoma longifoliaSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    Descriptor(s) : antineoplastic propertiesantineoplastic propertiesSubject Category: Properties
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    , carcinomacarcinomaSubject Category: Diseases, Disorders, and Symptoms
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    , cell linescell linesSubject Category: Organism Groups
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    , chemical compositionchemical compositionSubject Category: Properties
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    , cytotoxicitycytotoxicitySubject Category: Properties
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    , liverliverSubject Category: Anatomical and Morphological Structures
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    , medicinal plantsmedicinal plantsSubject Category: Commodities and Products
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    , neoplasmsneoplasmsSubject Category: Diseases, Disorders, and Symptoms
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    , pelvispelvisSubject Category: Anatomical and Morphological Structures
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    , phytochemicalsphytochemicalsSubject Category: Chemicals and Chemical Groups
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    , plant compositionplant compositionSubject Category: Properties
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    , plant extractsplant extractsSubject Category: Commodities and Products
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    , prostateprostateSubject Category: Anatomical and Morphological Structures
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    , rootsrootsSubject Category: Anatomical and Morphological Structures
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    Identifier(s) : anti-neoplastic properties, cancers, chemical constituents of plants, drug plants, medicinal herbs, officinal plants, Tongkat Ali

    Geographical Location(s) : MalaysiamalaysiaSubject Category: Geographic Entities
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    Broader term(s) : EurycomaeurycomaSubject Category: Organism Names
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    , SimaroubaceaesimaroubaceaeSubject Category: Organism Names
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    , SapindalessapindalesSubject Category: Organism Names
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    , eudicotseudicotsSubject Category: Organism Names
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    , angiospermsangiospermsSubject Category: Organism Names
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    , SpermatophytaspermatophytaSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , APEC countriesapec countriesSubject Category: Institutions and Organisations
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    , ASEAN Countriesasean countriesSubject Category: Institutions and Organisations
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    , Commonwealth of Nationscommonwealth of nationsSubject Category: Institutions and Organisations
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    , Developing Countriesdeveloping countriesSubject Category: Miscellaneous
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    , South East Asiasouth east asiaSubject Category: Geographic Entities
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    , AsiaasiaSubject Category: Geographic Entities
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    , Threshold Countriesthreshold countriesSubject Category: Miscellaneous
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