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  • Course of infection and immune responses in the respiratory tract of IBV infected broilers after superinfection with E. coli.

    Author(s) : Matthijs, M. G. R.Ariaans, M. P.Dwars, R. M.Eck, J. H. H. vanBouma, A.Stegeman, A.Vervelde, L.

    Author Affiliation : Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, Netherlands.

    Author Email : m.g.r.matthijs@uu.nl

    Journal article : Veterinary Immunology and Immunopathology 2009 Vol.127 No.1/2 pp.77-84 ref.26

    Abstract : Colibacillosis results from infection with avian pathogenic Escherichia coli bacteriabacteriaSubject Category: Organism Names
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    . Healthy broilersbroilersSubject Category: Organism Groups
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    are resistant to inhaled E. coli, but previous infection with vaccine or virulent strainsstrainsSubject Category: Organism Groups
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    of Infectious Bronchitis Virusinfectious bronchitis virusSubject Category: Organism Names
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    (IBV) predisposes birdsbirdsSubject Category: Organism Names
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    for severe colibacillosis. The aim of this study was to investigate how IBV affects the course of events upon infection with E. coli. Broilers were inoculated with IBV H120 vaccine virus or virulent M41 and challenged 5 days later with E. coli 506. A PBS and E. coli group without previous virus inoculationinoculationSubject Category: Techniques, Methodologies and Equipment
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    were included. Sections of tracheatracheaSubject Category: Anatomical and Morphological Structures
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    , lung and airsacs were stained for CD4, CD8, γδ-TCR, αβ1-TCR, and for macrophagesmacrophagesSubject Category: Anatomical and Morphological Structures
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    (KUL-01) and both pathogenspathogensSubject Category: Organism Groups
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    . Changes in the mucociliary barrier of trachea, lung and airsacs did not predispose for bacterial superinfection. The disease in the lungslungsSubject Category: Anatomical and Morphological Structures
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    of the E. coli group and both IBV/E. coli groups was similar. LesionslesionsSubject Category: Diseases, Disorders, and Symptoms
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    in the airsacs were more pronounced and of longer duration in the IBV/E. coli groups. The immunocytological changes differed substantially between the E. coli group and both IBV/E. coli groups. In trachea, lungs and airsacs the CD4+ and CD8+ populations were significantly larger than in the E. coli and PBS groups. In the lungs and the airsacs the macrophages were more numerous in the IBV/E. coli and the E. coli groups than in the PBS group. The presence of high numbers of T cells and macrophages in IBV infected birds most likely induced an altered immune responseimmune responseSubject Category: Natural Processes
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    , which is responsible for the enhanced clinical signs of colibacillosis.

    ISSN : 0165-2427

    DOI : 10.1016/j.vetimm.2008.09.016

    URL : http://www.sciencedirect.com/science/...

    Record Number : 20093101458

    Publisher : Elsevier

    Location of publication : Amsterdam

    Country of publication : Netherlands

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : BacteriabacteriaSubject Category: Organism Names
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    , birdsbirdsSubject Category: Organism Names
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    , EscherichiaescherichiaSubject Category: Organism Names
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    , Escherichia coliescherichia coliSubject Category: Organism Names
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    , fowlsfowlsSubject Category: Organism Names
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    , infectious bronchitis virusinfectious bronchitis virusSubject Category: Organism Names
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    , virusesvirusesSubject Category: Organism Names
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    Descriptor(s) : avian infectious bronchitisavian infectious bronchitisSubject Category: Diseases, Disorders, and Symptoms
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    , bacterial diseasesbacterial diseasesSubject Category: Diseases, Disorders, and Symptoms
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    , broilersbroilersSubject Category: Organism Groups
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    , bronchitisbronchitisSubject Category: Diseases, Disorders, and Symptoms
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    , CD4 antigenscd4 antigensSubject Category: Chemicals and Chemical Groups
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    , CD8 antigenscd8 antigensSubject Category: Chemicals and Chemical Groups
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    , Escherichia coli infectionsescherichia coli infectionsSubject Category: Diseases, Disorders, and Symptoms
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    , Escherichia infectionsescherichia infectionsSubject Category: Diseases, Disorders, and Symptoms
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    , immune responseimmune responseSubject Category: Natural Processes
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    , immunizationimmunizationSubject Category: Techniques, Methodologies and Equipment
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    , immunologyimmunologySubject Category: Disciplines, Occupations and Industries
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    , infectionsinfectionsSubject Category: Diseases, Disorders, and Symptoms
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    , infectious diseasesinfectious diseasesSubject Category: Diseases, Disorders, and Symptoms
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    , inhalationinhalationSubject Category: Miscellaneous
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    , inoculationinoculationSubject Category: Techniques, Methodologies and Equipment
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    , lesionslesionsSubject Category: Diseases, Disorders, and Symptoms
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    , lungslungsSubject Category: Anatomical and Morphological Structures
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    , macrophagesmacrophagesSubject Category: Anatomical and Morphological Structures
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    , pathogenspathogensSubject Category: Organism Groups
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    , poultrypoultrySubject Category: Organism Groups
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    , respiratory systemrespiratory systemSubject Category: Anatomical and Morphological Structures
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    , strainsstrainsSubject Category: Organism Groups
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    , T lymphocytest lymphocytesSubject Category: Anatomical and Morphological Structures
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    , tracheatracheaSubject Category: Anatomical and Morphological Structures
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    , vaccinesvaccinesSubject Category: Commodities and Products
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    , viral diseasesviral diseasesSubject Category: Diseases, Disorders, and Symptoms
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    , virulencevirulenceSubject Category: Miscellaneous
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    , respiratory diseasesrespiratory diseasesSubject Category: Diseases, Disorders, and Symptoms
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    Identifier(s) : bacterial infections, bacterioses, bacterium, CD4, CD8, chickens, colibacteriosis, communicable diseases, domesticated birds, E. coli, IBV infection, immune sensitization, immunity reactions, immunological reactions, superinfections, T cells, viral infections

    Broader term(s) : prokaryotesprokaryotesSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , EnterobacteriaceaeenterobacteriaceaeSubject Category: Organism Names
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    , EnterobacterialesenterobacterialesSubject Category: Organism Names
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    , GammaproteobacteriagammaproteobacteriaSubject Category: Organism Names
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    , ProteobacteriaproteobacteriaSubject Category: Organism Names
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    , BacteriabacteriaSubject Category: Organism Names
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    , EscherichiaescherichiaSubject Category: Organism Names
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    , Gallus gallusgallus gallusSubject Category: Organism Names
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    , GallusgallusSubject Category: Organism Names
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    , PhasianidaephasianidaeSubject Category: Organism Names
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    , GalliformesgalliformesSubject Category: Organism Names
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    , birdsbirdsSubject Category: Organism Names
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    , Avian coronavirusavian coronavirusSubject Category: Organism Names
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    , GammacoronavirusgammacoronavirusSubject Category: Organism Names
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    , CoronavirinaecoronavirinaeSubject Category: Organism Names
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    , CoronaviridaecoronaviridaeSubject Category: Organism Names
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    , NidoviralesnidoviralesSubject Category: Organism Names
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    , positive-sense ssRNA Virusespositive-sense ssrna virusesSubject Category: Organism Names
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    , ssRNA Virusesssrna virusesSubject Category: Organism Names
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    , RNA Virusesrna virusesSubject Category: Organism Names
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    , virusesvirusesSubject Category: Organism Names
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