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  • Cytokine expression by neutrophils of adult horses stimulated with virulent and avirulent Rhodococcus equi in vitro.

    Author(s) : Nerren, J. R.Payne, S.Halbert, N. D.Martens, R. J.Cohen, N. D.

    Author Affiliation : Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA.

    Author Email : ncohen@cvm.tamu.edu

    Journal article : Veterinary Immunology and Immunopathology 2009 Vol.127 No.1/2 pp.135-143 ref.many

    Abstract : Rhodococcus equirhodococcus equiSubject Category: Organism Names
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    is an intracellular pathogen of macrophagesmacrophagesSubject Category: Anatomical and Morphological Structures
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    that causes rhodococcal pneumoniapneumoniaSubject Category: Diseases, Disorders, and Symptoms
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    in foalsfoalsSubject Category: Organism Groups
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    and immunocompromised people. Evidence exists that neutrophilsneutrophilsSubject Category: Anatomical and Morphological Structures
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    play a vital role in resistanceresistanceSubject Category: Properties
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    to infection with R. equi; however, the means by which neutrophils exert their effectseffectsSubject Category: Properties
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    have not been clearly defined. In addition to directly killing bacteria, neutrophils also may exert a protective effect by linking innate and adaptive immune responses. In the present study we evaluated the cytokine expression profiles of adult equine neutrophils in response to stimulationstimulationSubject Category: Techniques, Methodologies and Equipment
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    with isogenic strainsstrainsSubject Category: Organism Groups
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    of virulent and avirulent R. equi in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    . After 2 and 4 h incubationincubationSubject Category: Miscellaneous
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    with virulent or avirulent R. equi, adult equine neutrophils expressed significantly (P<0.05) greater tumor necrosis factortumor necrosis factorSubject Category: Chemicals and Chemical Groups
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    tumor necrosis factorSubject Category: Chemicals and Chemical Groups
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    alpha (TNFα), interleukin (IL)-12p40, IL-6, IL-8 and IL-23p19 mRNA, but not interferon gamma (IFNγ) or IL-12p35 mRNA than unstimulated neutrophils. Furthermore, virulent R. equi induced significantly greater IL-23p19 mRNA than avirulent R. equi. These results demonstrate that R. equi-stimulated neutrophils are a source of many proinflammatory cytokinescytokinesSubject Category: Chemicals and Chemical Groups
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    . Furthermore, these results suggest that IL-23 may be preferentially expressed over IL-12 in response to exposure with R. equi, and that this response may be more strongly induced by virulent R. equi than avirulent R. equi. Collectively, the data presented herein suggest a non-phagocytic role for neutrophils that may influence the type of adaptive immune responseimmune responseSubject Category: Natural Processes
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    to R. equi.

    ISSN : 0165-2427

    DOI : 10.1016/j.vetimm.2008.10.003

    Record Number : 20093101464

    Publisher : Elsevier

    Location of publication : Amsterdam

    Country of publication : Netherlands

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : BacteriabacteriaSubject Category: Organism Names
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    , EquusequusSubject Category: Organism Names
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    , horseshorsesSubject Category: Organism Names
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    , Rhodococcus equirhodococcus equiSubject Category: Organism Names
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    Descriptor(s) : cytokinescytokinesSubject Category: Chemicals and Chemical Groups
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    , effectseffectsSubject Category: Properties
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    , foalsfoalsSubject Category: Organism Groups
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    , immune responseimmune responseSubject Category: Natural Processes
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    , immunocompromised hostsimmunocompromised hostsSubject Category: Organism Groups
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    , immunologyimmunologySubject Category: Disciplines, Occupations and Industries
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    , in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    , incubationincubationSubject Category: Miscellaneous
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    , infectionsinfectionsSubject Category: Diseases, Disorders, and Symptoms
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    , inflammationinflammationSubject Category: Diseases, Disorders, and Symptoms
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    , interleukinsinterleukinsSubject Category: Chemicals and Chemical Groups
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    , macrophagesmacrophagesSubject Category: Anatomical and Morphological Structures
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    , messenger RNAmessenger rnaSubject Category: Chemicals and Chemical Groups
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    , necrosisnecrosisSubject Category: Diseases, Disorders, and Symptoms
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    , neutrophilsneutrophilsSubject Category: Anatomical and Morphological Structures
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    , pneumoniapneumoniaSubject Category: Diseases, Disorders, and Symptoms
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    , protectionprotectionSubject Category: Techniques, Methodologies and Equipment
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    , resistanceresistanceSubject Category: Properties
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    , stimulationstimulationSubject Category: Techniques, Methodologies and Equipment
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    , strainsstrainsSubject Category: Organism Groups
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    , tumour necrosis factortumour necrosis factorSubject Category: Chemicals and Chemical Groups
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    , virulencevirulenceSubject Category: Miscellaneous
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    , interferonsinterferonsSubject Category: Chemicals and Chemical Groups
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    , interferon-gammainterferon-gammaSubject Category: Chemicals and Chemical Groups
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    , respiratory diseasesrespiratory diseasesSubject Category: Diseases, Disorders, and Symptoms
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    Identifier(s) : bacterium, cachectin, cachexin, host resistance, immunity reactions, immunological reactions, interferoninterferonSubject Category: Chemicals and Chemical Groups
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    , mRNA, Rhodococcus, tumor necrosis factortumor necrosis factorSubject Category: Chemicals and Chemical Groups
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    Broader term(s) : prokaryotesprokaryotesSubject Category: Organism Names
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    , EquusequusSubject Category: Organism Names
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    , EquidaeequidaeSubject Category: Organism Names
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    , PerissodactylaperissodactylaSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , Rhodococcus (Bacteria)rhodococcus (bacteria)Subject Category: Organism Names
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    , NocardiaceaenocardiaceaeSubject Category: Organism Names
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    , CorynebacterineaecorynebacterineaeSubject Category: Organism Names
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    , ActinomycetalesactinomycetalesSubject Category: Organism Names
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    , ActinobacteridaeactinobacteridaeSubject Category: Organism Names
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    , ActinobacteriaactinobacteriaSubject Category: Organism Names
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    , BacteriabacteriaSubject Category: Organism Names
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