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  • Pharmacokinetics and tissue residues of marbofloxacin in crucian carp (Carassius auratus) after oral administration.

    Author(s) : Zhu YanLeiTan YePingWang ChunMeiZhang NanLiu YunPingLiu LinaLi ChunMingLu XiaoCongCao JiYue

    Author Affiliation : College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

    Author Email : caojiyue@mail.hzau.edu.cn

    Journal article : Aquaculture Research 2009 Vol.40 No.6 pp.696-709 ref.47

    Abstract : PharmacokineticspharmacokineticsSubject Category: Miscellaneous
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    and residue elimination of marbofloxacin (MBF) were studied in crucian carp (CarassiuscarassiusSubject Category: Organism Names
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    auratus
    , 250±30 g) kept at two water temperatures of 15 and 25°C. Marbofloxacin concentrations in plasma and tissues were analysed by means of high-performance liquid chromatography using an ultraviolet detector. The limits of detection were 0.02 µg mL-1, 0.02 µg g-1, 0.025 µg g-1, 0.02 µg g-1 and 0.025 µg g-1 in plasma and muscle, skinskinSubject Category: Anatomical and Morphological Structures
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    , liverliverSubject Category: Anatomical and Morphological Structures
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    and kidney respectively. Fish were administered orally at a single dosage of 10 mg kg-1 body weight in the PK group. The data were fitted to two-compartment open models at both temperatures. At 15°C, the absorption half-life (t1/2Ka) and distribution half-life (t1/2α) of the drug were 0.36 and 4.48 h respectively. The corresponding values at 25°C were 0.23 and 0.87 h respectively. The elimination half-life (t1/2β) was 50.75 h at 15°C and 25.05 h at 25°C. The maximum MBF concentration (Cmax) differed little between 15 (6.43 µg mL-1) and 25°C (8.36 µg mL-1). The time to peak concentration was 1.74 h at 15°C and 0.78 h at 25°C. The apparent volume of distribution (Vd/F) of MBF was estimated to be 1.36 and 0.87 L kg-1 at 15 and 25°C respectively. The area under the concentration-time curve (AUC) was 301.80 µg mL-1 h at 15°C and 182.80 µg mL-1 h at 25°C. The total clearance of MBF was computed as 0.03 and 0.05 L h-1 kg-1 at 15 and 25°C respectively. After repeated oral administrationoral administrationSubject Category: Miscellaneous
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    at a dosage of 10 mg kg-1 body weight per day for 3 days, the results showed that the elimination half-lives (t1/2Ke) of MBF from all tissues at 15°C were longer than that at 25°C. Therefore, water temperaturewater temperatureSubject Category: Properties
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    is an important factor to be considered when deciding a reasonable withdrawal time.

    ISSN : 1355-557X

    DOI : 10.1111/j.1365-2109.2008.02146.x

    Record Number : 20093102702

    Publisher : Blackwell Publishing

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : goldfishgoldfishSubject Category: Organism Names
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    Descriptor(s) : aquatic animalsaquatic animalsSubject Category: Organism Groups
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    , aquatic organismsaquatic organismsSubject Category: Organism Groups
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    , kidneyskidneysSubject Category: Anatomical and Morphological Structures
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    , liverliverSubject Category: Anatomical and Morphological Structures
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    , musclesmusclesSubject Category: Anatomical and Morphological Structures
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    , oral administrationoral administrationSubject Category: Miscellaneous
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    , pharmacokineticspharmacokineticsSubject Category: Miscellaneous
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    , skinskinSubject Category: Anatomical and Morphological Structures
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    , water temperaturewater temperatureSubject Category: Properties
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    , fluoroquinolone antibioticsfluoroquinolone antibioticsSubject Category: Chemicals and Chemical Groups
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    , antibioticsantibioticsSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : aquatic species, Carassius auratus, dermis

    Broader term(s) : CarassiuscarassiusSubject Category: Organism Names
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    , CyprinidaecyprinidaeSubject Category: Organism Names
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    , CypriniformescypriniformesSubject Category: Organism Names
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    , OsteichthyesosteichthyesSubject Category: Organism Names
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    , fishesfishesSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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