Author(s) :
Zhu YanLei
;
Tan YePing
;
Wang ChunMei
;
Zhang Nan
;
Liu YunPing
;
Liu Lina
;
Li ChunMing
;
Lu XiaoCong
;
Cao JiYue
Author Affiliation :
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Author Email :
caojiyue@mail.hzau.edu.cn
Journal article
:
Aquaculture Research
2009
Vol.40
No.6
pp.696-709
ref.47
Abstract :
PharmacokineticspharmacokineticsSubject Category: Miscellaneous
see more details and residue elimination of marbofloxacin (MBF) were studied in crucian carp (
CarassiuscarassiusSubject Category: Organism Names
see more details auratus, 250±30 g) kept at two water temperatures of 15 and 25°C. Marbofloxacin concentrations in plasma and tissues were analysed by means of high-performance liquid chromatography using an ultraviolet detector. The limits of detection were 0.02 µg mL
-1, 0.02 µg g
-1, 0.025 µg g
-1, 0.02 µg g
-1 and 0.025 µg g
-1 in plasma and muscle,
skinskinSubject Category: Anatomical and Morphological Structures
see more details,
liverliverSubject Category: Anatomical and Morphological Structures
see more details and kidney respectively. Fish were administered orally at a single dosage of 10 mg kg
-1 body weight in the PK group. The data were fitted to two-compartment open models at both temperatures. At 15°C, the absorption half-life (
t1/2Ka) and distribution half-life (
t1/2α) of the drug were 0.36 and 4.48 h respectively. The corresponding values at 25°C were 0.23 and 0.87 h respectively. The elimination half-life (
t1/2β) was 50.75 h at 15°C and 25.05 h at 25°C. The maximum MBF concentration (
Cmax) differed little between 15 (6.43 µg mL
-1) and 25°C (8.36 µg mL
-1). The time to peak concentration was 1.74 h at 15°C and 0.78 h at 25°C. The apparent volume of distribution (
Vd/
F) of MBF was estimated to be 1.36 and 0.87 L kg
-1 at 15 and 25°C respectively. The area under the concentration-time curve (AUC) was 301.80 µg mL
-1 h at 15°C and 182.80 µg mL
-1 h at 25°C. The total clearance of MBF was computed as 0.03 and 0.05 L h
-1 kg
-1 at 15 and 25°C respectively. After repeated
oral administrationoral administrationSubject Category: Miscellaneous
see more details at a dosage of 10 mg kg
-1 body weight per day for 3 days, the results showed that the elimination half-lives (
t1/2Ke) of MBF from all tissues at 15°C were longer than that at 25°C. Therefore,
water temperaturewater temperatureSubject Category: Properties
see more details is an important factor to be considered when deciding a reasonable withdrawal time.
ISSN :
1355-557X
DOI :
10.1111/j.1365-2109.2008.02146.x
Record Number :
20093102702
Publisher :
Blackwell Publishing
Location of publication :
Oxford
Country of publication :
UK
Language of text :
English
Indexing terms for this abstract:
Organism descriptor(s) :
goldfishgoldfishSubject Category: Organism Names
see more details
Descriptor(s) :
aquatic animalsaquatic animalsSubject Category: Organism Groups
see more details, aquatic organismsaquatic organismsSubject Category: Organism Groups
see more details, kidneyskidneysSubject Category: Anatomical and Morphological Structures
see more details, liverliverSubject Category: Anatomical and Morphological Structures
see more details, musclesmusclesSubject Category: Anatomical and Morphological Structures
see more details, oral administrationoral administrationSubject Category: Miscellaneous
see more details, pharmacokineticspharmacokineticsSubject Category: Miscellaneous
see more details, skinskinSubject Category: Anatomical and Morphological Structures
see more details, water temperaturewater temperatureSubject Category: Properties
see more details, fluoroquinolone antibioticsfluoroquinolone antibioticsSubject Category: Chemicals and Chemical Groups
see more details, antibioticsantibioticsSubject Category: Chemicals and Chemical Groups
see more details
Identifier(s) :
aquatic species, Carassius auratus, dermis
Broader term(s) :
CarassiuscarassiusSubject Category: Organism Names
see more details, CyprinidaecyprinidaeSubject Category: Organism Names
see more details, CypriniformescypriniformesSubject Category: Organism Names
see more details, OsteichthyesosteichthyesSubject Category: Organism Names
see more details, fishesfishesSubject Category: Organism Names
see more details, vertebratesvertebratesSubject Category: Organism Names
see more details, ChordatachordataSubject Category: Organism Names
see more details, animalsanimalsSubject Category: Organism Names
see more details, eukaryoteseukaryotesSubject Category: Organism Names
see more details