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  • Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study.

    Author(s) : Czeizel, A. E.Puhó, E. H.Langmar, Z.Ács, N.Bánhidy, F.

    Author Affiliation : Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary.

    Author Email : czeizel@interware.hu

    Journal article : European Journal of Obstetrics & Gynecology and Reproductive Biology 2010 Vol.148 No.2 pp.135-140

    Abstract : Objective: Periconceptional folic acid or multivitamin supplementation is recommended for prospective pregnant women to prevent neural-tube defects. The question is whether it is worth continuing these supplementations after the first trimester of pregnancy or not. Thus the possible fetal growth promoting and/or preterm birth reducing effect of vitamin supplements in the second and mainly in the third trimester was studied. Study design: Comparison of birth outcomes of singletons born to primiparous pregnant women with prospectively and medically recorded vitamin supplement in the population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA), 1980-1996 contained 6293, 169, and 311 primiparae with folic acid alone, multivitamins and folic acid+multivitamin supplementation, respectively, and their data were compared to the data of 7319 pregnant women without folic acid and folic acid-containing multivitamin supplementation as reference. Results: Mean gestational age was 0.3 week longer and mean birth weight was by 37 g higher in the group of folic acid alone, than in the reference group (39.2 weeks; 3216 g). The rate of preterm births (7.6%) was significantly lower compared with the reference sample (11.8%), but the rate of low birth weight newborns did not show significant reduction. Folic acid alone in the third trimester associated with 0.6 week longer gestational age and a more significant reduction in the rate of preterm births (4.8%). Conclusions: Minor increase in mean birth weight after high dose of folic acid supplementation during pregnancy would not be expected to result in too large babies; however, the significant reduction in the rate of preterm births may have great public health benefit.

    ISSN : 0301-2115

    DOI : 10.1016/j.ejogrb.2009.10.016

    URL : http://www.sciencedirect.com/science?...

    Record Number : 20103059085

    Publisher : Elsevier Ireland

    Location of publication : Shannon

    Country of publication : Irish Republic

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : man

    Descriptor(s) : birth weight, folic acid, human diseases, maternal effects, mothers, pregnancy, pregnancy complications, prematurity, vitamin supplements

    Identifier(s) : folacin, folate, gestation, matrocliny

    Broader term(s) : Homo, Hominidae, primates, mammals, vertebrates, Chordata, animals, eukaryotes