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  • GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans.

    Author(s) : Kim SangHeonKim SangHoonYoon HoJooShin DongHoPark SungSooKim YounSeupPark JaeSeukJee YoungKoo

    Author Affiliation : Department of Internal Medicine, Hanyang University College of Medicine, Haengdang-dong 17, Seongdong-gu, Seoul 133-792, Korea Republic.

    Author Email : sangheonkim@hanyang.ac.krkshn1134@eulji.ac.krhjyoon@hanyang.ac.krshindh@hanyang.ac.krsspark@hanyang.ac.krdrys99@dankook.ac.krjspark@dankook.ac.krykjee@dku.edu

    Journal article : Tuberculosis 2010 Vol.90 No.1 pp.39-43 ref.25

    Abstract : Adverse reactions induced by antituberculosis drugs (ATD) often result in serious morbidities, impeding scheduled treatment and cure. In the development of ATD-induced adverse reactions, glutathione S-transferase has been suggested to play a protective role as an intracellular scavenger by conjugating toxic reactive metabolites of ATD. This study examined the association of null mutations in GST enzyme genes (GSTT1 and GSTM1) with the development of ATD-induced hepatitis and cutaneous reactions. We compared the frequencies of GSTT1 and GSTM1 null mutations in 57 patients with hepatitis, 94 patients with cutaneous adverse reactions, and 190 ATD-tolerant controls. The frequency of null mutations in GSTT1 and GSTM1 in patients with ATD-induced hepatitis was not significantly different from that of controls (59.6% vs. 54.2% and 45.6% vs. 54.7%, respectively). Additionally, no significant difference was observed in the frequency of either null mutation in patients with ATD-induced cutaneous reactions, including maculopapular eruption, compared with controls (58.5% vs. 54.1% for GSTT1 and 59.6% vs. 54.6% for GSTM1). These findings indicate that GSTT1 and GSTM1 null mutations are not associated with the development of ATD-induced hepatitis or cutaneous reactions in this Korean population, and suggest that glutathione S-transferase enzymes do not play important roles in the pathogenesis of these conditions.

    ISSN : 1472-9792

    DOI : 10.1016/j.tube.2009.12.001

    URL : http://www.sciencedirect.com/science/...

    Record Number : 20103060559

    Publisher : Elsevier Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : man, Mycobacterium tuberculosis

    Descriptor(s) : adverse effects, antituberculous agents, drug therapy, genes, glutathione transferase, hepatitis, human diseases, mutational analysis, mutations, pathogenesis, skin diseases, tuberculosis

    Identifier(s) : adverse reactions, bacterium, chemotherapy, dermatoses, ligandin, South Korea

    Geographical Location(s) : Korea Republic

    Broader term(s) : Homo, Hominidae, primates, mammals, vertebrates, Chordata, animals, eukaryotes, Mycobacterium, Mycobacteriaceae, Corynebacterineae, Actinomycetales, Actinobacteridae, Actinobacteria, Bacteria, prokaryotes, APEC countries, Developing Countries, East Asia, Asia, OECD Countries, Threshold Countries