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  • Immune response of BALB/c mice against an experimental vaccine of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with BCG or Mycobacterium vaccae.

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    Author(s) : Rostami, M. N.Keshavarz, H.Khamesipour, A.

    Author Affiliation : Medical Parasitology and Mycology Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.

    Author Email : Khamesipour_ali@yahoo.com

    Journal article : Tropical Biomedicine 2010 Vol.27 No.1 pp.89-102 ref.50

    Abstract : Immune response in BALB/c mice immunized 3 times with different doses (50 µg or 200 µg of protein) of alum precipitated autoclaved Leishmania major vaccine (Alum-ALM) mixed with either BCG (1×107 CFU) or different doses of killed Mycobacterium vaccae (1×106, 1×107) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-γ production, a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.

    ISSN : 0127-5720

    URL : http://www.msptm.org/journal.html

    Record Number : 20103089341

    Publisher : Malaysian Society of Parasitology and Tropical Medicine

    Location of publication : Kuala Lumpur

    Country of publication : Malaysia

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Leishmania, Leishmania major, mice, Protozoa

    Descriptor(s) : animal models, immune response, immunization, infections, interferon, interleukin 4, laboratory animals, leishmaniasis, parasites, parasitoses, protozoal infections, vaccination, vaccines

    Identifier(s) : immune sensitization, immunity reactions, immunological reactions, leishmaniosis, parasitic diseases, parasitic infestations, parasitosis, protozoal diseases

    Broader term(s) : Leishmania, Trypanosomatidae, Kinetoplastida, Sarcomastigophora, Protozoa, eukaryotes, Muridae, rodents, mammals, vertebrates, Chordata, animals