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Rostami, M. N.; Keshavarz, H.; Khamesipour, A.
Author Affiliation :
Medical Parasitology and Mycology Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
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Immune response in BALB/c mice immunized 3 times with different doses (50 µg or 200 µg of protein) of alum precipitated autoclaved Leishmania major vaccine (Alum-ALM) mixed with either BCG (1×107 CFU) or different doses of killed Mycobacterium vaccae (1×106, 1×107) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-γ production, a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.
Record Number :
Malaysian Society of Parasitology and Tropical Medicine
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Indexing terms for this abstract:
Organism descriptor(s) :
Leishmania, Leishmania major, mice, Protozoa
animal models, immune response, immunization, infections, interferon, interleukin 4, laboratory animals, leishmaniasis, parasites, parasitoses, protozoal infections, vaccination, vaccines
immune sensitization, immunity reactions, immunological reactions, leishmaniosis, parasitic diseases, parasitic infestations, parasitosis, protozoal diseases
Broader term(s) :
Leishmania, Trypanosomatidae, Kinetoplastida, Sarcomastigophora, Protozoa, eukaryotes, Muridae, rodents, mammals, vertebrates, Chordata, animals