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  • Natural polysaccharide hydrogel dexibuprofen microbeads for oral sustained drug delivery.

    Author(s) : Manjanna, K. M.Shivakumar, B.Kumar, T. M. P.

    Author Affiliation : Department of Pharmaceutics, T.V.M. College of Pharmacy, Bellary Karnataka, India.

    Author Email : kmhuruli@rediffmail.com

    Journal article : Journal of Pharmacy Research 2009 Vol.2 No.7 pp.1271-1278 ref.21

    Abstract : The successful optimization and development of drug entity, design of dosage form then plays important role. Hence, research continuously keeps on searching for ways to deliver drugs over an extended period of time. Dexibuprofen a novel NSAID used in the treatment of rheumatoid arthritis which has a short half-life approximately 3.5 h and dosing frequency 2-3 times daily, causes certain side effects like abdominal pain, gastritis, constipation, etc. In the present study, spherical microbeads are able to prolong the release of dexibuprofen were prepared by ionotropic gelation method, using sodium alginate in combination with guar gumguar gumSubject Category: Chemicals and Chemical Groups
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    , chitosan and pectin natural polysaccharide hydrogels as drug release modifiers in various proportions to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. All investigated properties showed satisfactory results. While increase in concentration of sodium alginate and other polymer dispersion increased sphericity, size distribution, flow properties and mean diameter of microbeads No significant drugpolymer interactions were observed in FT-IR studies. Drug entrapment efficiencies were obtained in the range of 70.4% to 95.2%. Increase in concentration of calcium chloride significantly affects the mean diameter but no appreciable change in morphology and release behavior. The shape and surface characteristics were determined by scanning electron microscopy (SEM) using gold sputter technique. The mean particle size was determined by an optical microscope. The physical state of the drug in the formulation was determined by differential scanning calorimetry (DSC). In-vitro drug release profile of dexibuprofen from microbeads was examined in simulated gastric fluid (SGF pH1.2) and simulated intestinal fluid (SIF pH 7.2). Microbeads coated with chitosan and guar gum aqueous polymer dispersion shows optimum level of sustained release and exhibited zero-order kinetics followed by super case-II transport.

    ISSN : 0974-6943

    URL : http://jpronline.info/.../400

    Record Number : 20103127133

    Publisher : Association of Pharmaceutical Innovators

    Location of publication : Madhya

    Country of publication : India

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Descriptor(s) : chemical compositionchemical compositionSubject Category: Properties
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    , controlled releasecontrolled releaseSubject Category: Techniques, Methodologies and Equipment
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    , drug delivery systemsdrug delivery systemsSubject Category: Techniques, Methodologies and Equipment
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    , formulationsformulationsSubject Category: Miscellaneous
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    , guar gumguar gumSubject Category: Chemicals and Chemical Groups
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    , gumsgumsSubject Category: Chemicals and Chemical Groups
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    , pharmacologypharmacologySubject Category: Disciplines, Occupations and Industries
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    , plant compositionplant compositionSubject Category: Properties
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    , polysaccharidespolysaccharidesSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : administration routes, chemical constituents of plants, complex carbohydrates, slow release