• Choose a colour
  • The complex interrelationships between chronic lung and liver disease: a review.

    Author(s) : Spagnolo, P.Zeuzem, S.Richeldi, L.Bois, R. M. du

    Author Affiliation : Center for Rare Lung Diseases, Department of Oncology, Haematology, and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy.

    Author Email : paolo.spagnolo@unimore.it

    Journal article : Journal of Viral Hepatitis 2010 Vol.17 No.6 pp.381-390 ref.103

    Abstract : Lung complications may occur as a result of hepatic disease from any cause and represent a highly heterogeneous group of conditions. Early recognition of such complications may be challenging but is crucial both in forming a meaningful differential diagnosis and in avoiding severe sequelae and irreversible damage. Although a number of different pathogenetic mechanisms are likely to be involved, chronic liver dysfunction may cause pulmonary manifestations because of alterations in the production or clearance of circulating cytokines and other mediators. This is likely to be the case in hepatopulmonary syndrome, portopulmonary hypertension and primary biliary cirrhosis, although their pathogenesis remains largely speculative. Moreover, the severity of lung manifestations may or may not correspond to that of liver impairment, making disease outcome often unpredictable. Congenital and inflammatory disorders, however, may primarily affect both the liver and lung. Apart from specific diseases, a number of medications can also result in pulmonary and hepatic toxic effects. This is particularly important with cytokine therapy - used to treat viral hepatitis, among other diseases - because treatment consists of drug discontinuation, which, in turn, may cause reactivation or progression of the underlying disease that the drug was used for. This review summarizes salient diagnostic and therapeutic aspects of these often misdiagnosed conditions and highlights, based on the most recent literature, the need for early referral of such patients to centres with specific expertise in the field. In fact, a multidisciplinary approach involving pulmonologists, hepatologists and, in particularly severe cases, transplant surgeons has been already proven successful.

    ISSN : 1352-0504

    DOI : 10.1111/j.1365-2893.2010.01307.x

    URL : http://www.blackwell-synergy.com/loi/jvh

    Record Number : 20103163519

    Publisher : Blackwell Publishing Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Hepatitis C virus, man

    Descriptor(s) : chronic diseases, cirrhosis, complications, hepatitis C, human diseases, liver, liver diseases, lungs, respiratory diseases, reviews

    Identifier(s) : liver cirrhosis, lung diseases

    Broader term(s) : Hepacivirus, Flaviviridae, positive-sense ssRNA Viruses, ssRNA Viruses, RNA Viruses, viruses, Homo, Hominidae, primates, mammals, vertebrates, Chordata, animals, eukaryotes