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  • Effects of two fractions of inspired oxygen on lung aeration and gas exchange in cats under inhalant anaesthesia.

    Author(s) : Staffieri, F.Monte, V. deMarzo, C. deGrasso, S.Crovace, A.

    Author Affiliation : Dipartimento dell'Emergenza e dei Trapianti di Organi (D.E.T.O.), Sezione di Chirurgia Veterinaria, Facoltá di Medicina Veterinaria, Universitá degli Studi di Bari, Strada Provinciale per Casamassima Km 3, 70010 Valenzano (Bari), Italy.

    Author Email : f.staffieri@veterinaria.uniba.it

    Journal article : Veterinary Anaesthesia and Analgesia 2010 Vol.37 No.6 pp.483-490 ref.25

    Abstract : Objective - To compare the effectseffectsSubject Category: Properties
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    of two fractions of inspired oxygen (FiO2) (0.4 and 1) on lung aerationaerationSubject Category: Techniques, Methodologies and Equipment
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    and gas exchangegas exchangeSubject Category: Miscellaneous
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    during general anaesthesiaanaesthesiaSubject Category: Miscellaneous
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    anaesthesiaSubject Category: Miscellaneous
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    in catscatsSubject Category: Organism Names
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    . Study design - Randomized, blinded, controlled study. AnimalsanimalsSubject Category: Organism Names
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    - Thirty healthy, mixed breed, client owned female cats. Materials and methods - Cats were premedicated intramuscularly with acepromazineacepromazineSubject Category: Chemicals and Chemical Groups
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    (0.03 mg kg-1) and medetomidinemedetomidineSubject Category: Chemicals and Chemical Groups
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    (0.015 mg kg-1). Anaesthesia was induced with propofolpropofolSubject Category: Chemicals and Chemical Groups
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    (5 mg kg-1) and, after orotracheal intubation, maintained with isofluraneisofluraneSubject Category: Chemicals and Chemical Groups
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    carried by either 100% oxygen (G100, n=15) or an oxygen-air mixture with 40% oxygen (G40, n=15). All cats were placed in dorsal recumbency and breathed spontaneously throughout the entire procedure. Following surgerysurgerySubject Category: Disciplines, Occupations and Industries
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    (ovariectomyovariectomySubject Category: Techniques, Methodologies and Equipment
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    ), a spiral computed tomographycomputed tomographySubject Category: Techniques, Methodologies and Equipment
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    (CT) of the thoraxthoraxSubject Category: Anatomical and Morphological Structures
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    was performed, arterial oxygen (PaO2) and carbon dioxidecarbon dioxideSubject Category: Chemicals and Chemical Groups
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    (PaCO2) tensions were measured and alveolar- arterial gradient of oxygen [P(A-a)O2] calculated. The CT images were analysed for lung aeration by the analysisanalysisSubject Category: Techniques, Methodologies and Equipment
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    of radiograph attenuations (Hounsfield units, HUhuSubject Category: Organism Names
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    huSubject Category: Animal Breeds
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    ), according to the following classificationclassificationSubject Category: Techniques, Methodologies and Equipment
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    : hyperinflated area (-1000 to -900 HU), normally aerated area (-900 to -500 HU), poorly aerated area (-500 to -100 HU) and non-aerated area (-100 to +100 HU). The groups were compared using oneway ANOVA. Results - Compared to G100, the normally-aerated lung area was significantly greater and the poorly-aerated and non-aerated areas were significantly smaller in G40. PaCO2 was similar in both groups. PaO2 and P(A-a)O2 were significantly higher in G100. In both groups, pulmonary atelectasisatelectasisSubject Category: Diseases, Disorders, and Symptoms
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    developed preferentially in the caudal lung fields. Conclusion - In cats anaesthetised with isoflurane, the administration of an FiO2 of >0.9 significantly impaired lung aeration and gas exchange as compared to an FiO2 of 0.4. Clinical relevance - An FiO2 of 0.4 may better preserve lung aeration and gas exchange in anaesthetised spontaneously breathing cats but monitoringmonitoringSubject Category: Techniques, Methodologies and Equipment
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    is essential to ensure oxygenation is adequate.

    ISSN : 1467-2987

    DOI : 10.1111/j.1467-2995.2010.00567.x

    Record Number : 20103374419

    Publisher : Blackwell Publishing Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : animalsanimalsSubject Category: Organism Names
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    , catscatsSubject Category: Organism Names
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    , HuhuSubject Category: Animal Breeds
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    Descriptor(s) : acepromazineacepromazineSubject Category: Chemicals and Chemical Groups
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    , aerationaerationSubject Category: Techniques, Methodologies and Equipment
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    , anaesthesiaanaesthesiaSubject Category: Miscellaneous
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    , analysisanalysisSubject Category: Techniques, Methodologies and Equipment
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    , atelectasisatelectasisSubject Category: Diseases, Disorders, and Symptoms
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    , carbon dioxidecarbon dioxideSubject Category: Chemicals and Chemical Groups
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    , classificationclassificationSubject Category: Techniques, Methodologies and Equipment
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    , computed tomographycomputed tomographySubject Category: Techniques, Methodologies and Equipment
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    , effectseffectsSubject Category: Properties
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    , gas exchangegas exchangeSubject Category: Miscellaneous
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    , isofluraneisofluraneSubject Category: Chemicals and Chemical Groups
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    , lungslungsSubject Category: Anatomical and Morphological Structures
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    , medetomidinemedetomidineSubject Category: Chemicals and Chemical Groups
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    , monitoringmonitoringSubject Category: Techniques, Methodologies and Equipment
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    , ovariectomyovariectomySubject Category: Techniques, Methodologies and Equipment
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    , ovariesovariesSubject Category: Anatomical and Morphological Structures
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    , propofolpropofolSubject Category: Chemicals and Chemical Groups
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    , reproductive organsreproductive organsSubject Category: Anatomical and Morphological Structures
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    , surgerysurgerySubject Category: Disciplines, Occupations and Industries
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    , thoraxthoraxSubject Category: Anatomical and Morphological Structures
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    , tomographytomographySubject Category: Techniques, Methodologies and Equipment
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    , respiratory diseasesrespiratory diseasesSubject Category: Diseases, Disorders, and Symptoms
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    Identifier(s) : acetylpromazine, anesthesiaanesthesiaSubject Category: Miscellaneous
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    , Hu-Yang, surveillance systems

    Broader term(s) : sheepsheepSubject Category: Organism Names
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    , OvisovisSubject Category: Organism Names
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    , BovidaebovidaeSubject Category: Organism Names
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    , ruminantsruminantsSubject Category: Organism Names
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    , ArtiodactylaartiodactylaSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , FelisfelisSubject Category: Organism Names
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    , FelidaefelidaeSubject Category: Organism Names
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    , FissipedafissipedaSubject Category: Organism Names
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    , carnivorescarnivoresSubject Category: Organism Names
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