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  • Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs.

    Author(s) : Lefebvre, D. J.Neyts, J.Clercq, K. de

    Author Affiliation : Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA-VAR, Veterinary and Agrochemical Research Centre, Groeselenberg 99, 1180 Brussel, Belgium.

    Author Email : dalef@var.fgov.be

    Journal article : Transboundary and Emerging Diseases 2010 Vol.57 No.6 pp.430-433 ref.10

    Abstract : Recent European guidelinesguidelinesSubject Category: Publications
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    facilitate the use of emergency vaccinesvaccinesSubject Category: Commodities and Products
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    during outbreaksoutbreaksSubject Category: Miscellaneous
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    of foot-and-mouth disease. Antiviral drugsdrugsSubject Category: Chemicals and Chemical Groups
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    could be used as a complementary measure. This study aimed at developing a small animal model to assess the in vivo activity of early antiviral lead molecules with anti-foot-and-mouth disease virusfoot-and-mouth disease virusSubject Category: Organism Names
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    (FMDV) activity in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    . In a first attempt, several FMDV strainsstrainsSubject Category: Organism Groups
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    were titrated in Balb/c micemiceSubject Category: Organism Names
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    . Inoculations with O1 Manisa or C1 Noville did not induce clinical disease, whereas Asia1 Shamir induced death too rapidly [i.e. within 4days post-inoculation (dpi)]. Therefore, we switched to severe combined immunodeficient mice which are frequently used as a model for viral infectionsinfectionsSubject Category: Diseases, Disorders, and Symptoms
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    and experimental therapeutics. Strain O1 Manisa did not induce clinical disease, but titrations with A22 IraqiraqSubject Category: Geographic Entities
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    , C1 Noville or Asia1 Shamir resulted in virus-induced morbiditymorbiditySubject Category: Miscellaneous
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    (including respiratory problems and weight loss) with subsequent mortalitymortalitySubject Category: Miscellaneous
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    . Inoculations with strain A22 Iraq resulted in a reproducible mean time of death of 6 dpi (this was shorter for the other strains). In this newly developed rodent model, strain A22 Iraq seems the most suited to assess the in vivo anti-FMDV activity of selective inhibitorsinhibitorsSubject Category: Chemicals and Chemical Groups
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    of FMDV.

    ISSN : 1865-1674

    DOI : 10.1111/j.1865-1682.2010.01169.x

    Record Number : 20103374843

    Publisher : Blackwell Publishing

    Location of publication : Berlin

    Country of publication : Germany

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Foot-and-mouth disease virusfoot-and-mouth disease virusSubject Category: Organism Names
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    , micemiceSubject Category: Organism Names
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    , rodentsrodentsSubject Category: Organism Names
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    , virusesvirusesSubject Category: Organism Names
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    Descriptor(s) : animal modelsanimal modelsSubject Category: Techniques, Methodologies and Equipment
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    , antiviral agentsantiviral agentsSubject Category: Chemicals and Chemical Groups
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    , clinical aspectsclinical aspectsSubject Category: Miscellaneous
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    , drugsdrugsSubject Category: Chemicals and Chemical Groups
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    , evaluationevaluationSubject Category: Techniques, Methodologies and Equipment
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    , foot and mouth diseasefoot and mouth diseaseSubject Category: Diseases, Disorders, and Symptoms
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    , guidelinesguidelinesSubject Category: Publications
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    , immunological deficiencyimmunological deficiencySubject Category: Diseases, Disorders, and Symptoms
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    , in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    , infectionsinfectionsSubject Category: Diseases, Disorders, and Symptoms
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    , infectious diseasesinfectious diseasesSubject Category: Diseases, Disorders, and Symptoms
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    , inhibitorsinhibitorsSubject Category: Chemicals and Chemical Groups
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    , morbiditymorbiditySubject Category: Miscellaneous
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    , mortalitymortalitySubject Category: Miscellaneous
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    , optimizationoptimizationSubject Category: Techniques, Methodologies and Equipment
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    , outbreaksoutbreaksSubject Category: Miscellaneous
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    , strainsstrainsSubject Category: Organism Groups
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    , therapytherapySubject Category: Techniques, Methodologies and Equipment
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    , vaccinesvaccinesSubject Category: Commodities and Products
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    , viral diseasesviral diseasesSubject Category: Diseases, Disorders, and Symptoms
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    , weight lossesweight lossesSubject Category: Miscellaneous
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    Identifier(s) : clinical picture, communicable diseases, death rate, FMD, foot-and-mouth disease, immune deficiency, immunodeficiency, in vivo, medicines, pharmaceuticals, recommendations, therapeutics, viral infections

    Geographical Location(s) : IraqiraqSubject Category: Geographic Entities
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    Broader term(s) : AphthovirusaphthovirusSubject Category: Organism Names
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    , PicornaviridaepicornaviridaeSubject Category: Organism Names
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    , PicornaviralespicornaviralesSubject Category: Organism Names
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    , positive-sense ssRNA Virusespositive-sense ssrna virusesSubject Category: Organism Names
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    , ssRNA Virusesssrna virusesSubject Category: Organism Names
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    , RNA Virusesrna virusesSubject Category: Organism Names
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    , virusesvirusesSubject Category: Organism Names
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    , MuridaemuridaeSubject Category: Organism Names
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    , rodentsrodentsSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , Developing Countriesdeveloping countriesSubject Category: Miscellaneous
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    , Middle Eastmiddle eastSubject Category: Geographic Entities
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    , Threshold Countriesthreshold countriesSubject Category: Miscellaneous
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    , West Asiawest asiaSubject Category: Geographic Entities
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    , AsiaasiaSubject Category: Geographic Entities
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