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  • Attempt to induce immunotolerance in xenotransplant using skin cells.

    Author(s) : Șereș, M.Tîrziu, E.Nichita, I.Cumpănășoiu, C.Cioca, D.

    Author Affiliation : Faculty of Veterinary Medicine Timisoara, 300645, Calea Aradului No. 119, Timisoara, Romania.

    Author Email : monica_seres@yahoo.com

    Journal article; Conference paper : Lucrări Științifice - Medicină Veterinară, Universitatea de Științe Agricole și Medicină Veterinară "Ion Ionescu de la Brad" Iași 2010 Vol.53 No.12(3) pp.853-857 ref.11

    Conference Title : Progress and perspectives in veterinary medicine, Iași, Romania, 10-11 June, 2010.

    Abstract : To test the potential of using epidermal and dermal cells suspension in inducing immunotolerance to concordant and discordant xenograftsxenograftsSubject Category: Techniques, Methodologies and Equipment
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    in poultrypoultrySubject Category: Organism Groups
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    . Materials and methods. Antigenic material obtained by processing with mechanical disaggregation system MEDIMACHINETM (Becton Dickinson, USA) the skinskinSubject Category: Anatomical and Morphological Structures
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    tissue taken from two donor dogsdogsSubject Category: Organism Names
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    and Muscovy ducksmuscovy ducksSubject Category: Organism Names
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    was inoculated in 120 Cobb 500 embryos. Inoculation was carried out in the ninth day of incubation, in the allantoidal vessels, and in the fifth day of incubation, in ovo. At the age of three weeks, the resulting birdsbirdsSubject Category: Organism Names
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    were tested for donor-recipient compatibility using mixed lymphocytic reaction; also, at this age, lymphocyte profile of the recipient individuals has been evaluated. Further checking was done by skin transplantationtransplantationSubject Category: Techniques, Methodologies and Equipment
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    at the age of four weeks. Results. Both laboratory tests and clinical assessment of skin xenografts demonstrated 100% incompatibility between donor and acceptor birds. Conclusion. Epidermal and dermal cells suspension is not a suitable antigenic material for immunotolerance induction in poultry.

    ISSN : 1454-7406

    URL : http://www.univagro-iasi.ro/.../

    Record Number : 20103374914

    Publisher : Universitatea de Științe Agricole și Medicină Veterinară"Ion Ionescu de la Brad" Iași

    Location of publication : Iași

    Country of publication : Romania

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : birdsbirdsSubject Category: Organism Names
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    , dogsdogsSubject Category: Organism Names
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    , ducksducksSubject Category: Organism Names
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    , Muscovy ducksmuscovy ducksSubject Category: Organism Names
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    Descriptor(s) : acquired immunotoleranceacquired immunotoleranceSubject Category: Miscellaneous
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    , clinical examinationclinical examinationSubject Category: Techniques, Methodologies and Equipment
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    , lymphocyteslymphocytesSubject Category: Anatomical and Morphological Structures
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    , natural immunotolerancenatural immunotoleranceSubject Category: Miscellaneous
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    , poultrypoultrySubject Category: Organism Groups
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    , skinskinSubject Category: Anatomical and Morphological Structures
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    , tissuestissuesSubject Category: Anatomical and Morphological Structures
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    , transplantationtransplantationSubject Category: Techniques, Methodologies and Equipment
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    , xenograftsxenograftsSubject Category: Techniques, Methodologies and Equipment
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    , xenotransplantationxenotransplantationSubject Category: Techniques, Methodologies and Equipment
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    Identifier(s) : dermis, domesticated birds, heterografts, heterotransplants, muscovies, muscovy

    Broader term(s) : CaniscanisSubject Category: Organism Names
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    , CanidaecanidaeSubject Category: Organism Names
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    , FissipedafissipedaSubject Category: Organism Names
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    , carnivorescarnivoresSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , AnatidaeanatidaeSubject Category: Organism Names
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    , AnseriformesanseriformesSubject Category: Organism Names
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    , birdsbirdsSubject Category: Organism Names
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    , CairinacairinaSubject Category: Organism Names
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