Ankur Choubey; Aadarsh Choubey; Promil Jain; Deepa Iyer; Patil, U. K.
Author Affiliation :
VNS Institute of Pharmacy, Neel bud, Bhopal (M.P), India.
Der Pharma Chemica
The effect of oral administration of aqueous and alcohol extracts of bark of Ceiba pentandra on calcium oxalate urolithiasis has been studied in male albino wistar rats. Ethylene glycol and ammonium chloride feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Ethylene glycol is a metabolic precursor of oxalate Regular administration of ethylene glycol caused hyperoxaluria in ethylene glycol fed animals and causes increased renal retention and excretion of oxalate, calcium and phosphate. Ammonium chloride used in conjunction with ethylene glycol to promote the deposition of Calcium oxalate crystals in rat kidneys. Supplementation with aqueous and alcohol extracts of bark of Ceiba pentandra significantly reduced the elevated urinary oxalate showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by preventive treatment using aqueous and alcohol extracts. The Result of the present study confirmed that Ceiba pentandra can be used as curative agents for urolithiasis.
Record Number :
Scholars Research Library
Country of publication :
Language of text :
Language of summary :
Indexing terms for this abstract:
Organism descriptor(s) :
Ceiba pentandra, plants, rats
animal models, antiurolithiatic properties, bark, calcium, kapok, medicinal plants, non-wood forest products, oxalic acid, phosphate, plant extracts, urolithiasis
anti-urolithiatic properties, drug plants, medicinal herbs, minor forest products, non-timber forest products, officinal plants
Geographical Location(s) :
India, Madhya Pradesh
Broader term(s) :
Ceiba, Malvaceae, Malvales, eudicots, angiosperms, Spermatophyta, plants, eukaryotes, Muridae, rodents, mammals, vertebrates, Chordata, animals, Commonwealth of Nations, Developing Countries, South Asia, Asia, India