• Choose a colour
  • Urine markers of kidney disorders and their risk associations in HIV-infected patients attending Nyanza Provincial General Hospital in Kisumu, Western Kenya.

    Author(s) : Opiyo, W. O.Ng'wena, A.Ofulla, V. O.

    Journal article : East African Medical Journal 2010 Vol.87 No.12 pp.495-501

    Abstract : Objective: To identify abnormal levels of urineurineSubject Category: Miscellaneous
    see more details
    metabolites and cells that serve as markers of existing kidney disorders in ambulatory HIV-infected patientspatientsSubject Category: People Groups
    see more details
    . Design: A cross sectional study. Setting: Nyanza Provincial General Hospital's patient support centre. Subjects: A total of 593 HIV infected patients were studied. Intervention: Dipstick urinalysis test was used to screen mid stream urine to detect constituents with altered levels. Results: Out of the 593 participants, the urine of 214 (36.1%) had abnormally altered levels of urine constituents, with more femalesfemalesSubject Category: Organism Groups
    see more details
    afflicted than males [41.5% vs. 27.8%; OR 1.84 (1.28-2.63), χ2=11.08, p=0.0009]. Urobilinogen was the most common urine metabolite while ketones were least commonly present. More participants had altered levels of leucocytes than erythrocyteserythrocytesSubject Category: Anatomical and Morphological Structures
    see more details
    in urine. Patients with pyuria were three times more likely to have elevated erythrocytes in their urine as well (χ2=34.37, p<0.0001). Similarly, the risk of having proteinuriaproteinuriaSubject Category: Diseases, Disorders, and Symptoms
    see more details
    was three times higher in patients with pyuria (p<0.0003, Fisher's test). Patients with erythrocytes in urine also had a threefold likelihood of having proteinuria (P<0.0003, Fisher's test). Fewer ARV users had abnormal urine markers [15.7% vs 24.3% OR 0.62 (0.41-0.94), χ2=5.2, p<0.05]. Conclusion: Metabolites and cellular markers of kidney disorders were prevalent in the urine of HIV patients especially females and those with pronounced immune depletion (CD4 counts equal to or below 500). ARVs use was associated with reduced manifestation of these markers.

    ISSN : 0012-835X

    URL : http://www.ajol.info/.../79996

    Record Number : 20123302551

    Publisher : Kenya Medical Association

    Location of publication : Nairobi

    Country of publication : Kenya

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : LentiviruslentivirusSubject Category: Organism Names
    see more details
    , manmanSubject Category: Organism Names
    see more details

    Descriptor(s) : complicationscomplicationsSubject Category: Diseases, Disorders, and Symptoms
    see more details
    , erythrocyteserythrocytesSubject Category: Anatomical and Morphological Structures
    see more details
    , femalesfemalesSubject Category: Organism Groups
    see more details
    , HIV infectionshiv infectionsSubject Category: Diseases, Disorders, and Symptoms
    see more details
    , human diseaseshuman diseasesSubject Category: Diseases, Disorders, and Symptoms
    see more details
    , human immunodeficiency viruseshuman immunodeficiency virusesSubject Category: Organism Groups
    see more details
    , kidney diseaseskidney diseasesSubject Category: Diseases, Disorders, and Symptoms
    see more details
    , kidneyskidneysSubject Category: Anatomical and Morphological Structures
    see more details
    , patientspatientsSubject Category: People Groups
    see more details
    , proteinuriaproteinuriaSubject Category: Diseases, Disorders, and Symptoms
    see more details
    , risk factorsrisk factorsSubject Category: Properties
    see more details
    , urineurineSubject Category: Miscellaneous
    see more details

    Identifier(s) : blood red cells, human immunodeficiency virus infections, kidney disorders, nephropathy, red blood cells, renal diseases, subsaharan Africa

    Geographical Location(s) : Africa South of Saharaafrica south of saharaSubject Category: Geographic Entities
    see more details
    , KenyakenyaSubject Category: Geographic Entities
    see more details

    Broader term(s) : LentiviruslentivirusSubject Category: Organism Names
    see more details
    , OrthoretrovirinaeorthoretrovirinaeSubject Category: Organism Names
    see more details
    , RetroviridaeretroviridaeSubject Category: Organism Names
    see more details
    , RNA Reverse Transcribing Virusesrna reverse transcribing virusesSubject Category: Organism Names
    see more details
    , virusesvirusesSubject Category: Organism Names
    see more details
    , HomohomoSubject Category: Organism Names
    see more details
    , HominidaehominidaeSubject Category: Organism Names
    see more details
    , primatesprimatesSubject Category: Organism Names
    see more details
    , mammalsmammalsSubject Category: Organism Names
    see more details
    , vertebratesvertebratesSubject Category: Organism Names
    see more details
    , ChordatachordataSubject Category: Organism Names
    see more details
    , animalsanimalsSubject Category: Organism Names
    see more details
    , eukaryoteseukaryotesSubject Category: Organism Names
    see more details
    , ACP Countriesacp countriesSubject Category: Institutions and Organisations
    see more details
    , Anglophone Africaanglophone africaSubject Category: Geographic Entities
    see more details
    , AfricaafricaSubject Category: Geographic Entities
    see more details
    , Commonwealth of Nationscommonwealth of nationsSubject Category: Institutions and Organisations
    see more details
    , Developing Countriesdeveloping countriesSubject Category: Miscellaneous
    see more details
    , East Africaeast africaSubject Category: Geographic Entities
    see more details
    , Africa South of Saharaafrica south of saharaSubject Category: Geographic Entities
    see more details