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  • Coenzyme Q10 in equine serum: response to supplementation.

    Author(s) : Sinatra, S. T.Chopra, R. K.Jankowitz, S.Horohov, D. W.Bhagavan, H. N.

    Author Affiliation : University of Connecticut School of Medicine, Farmington, CT 06030, USA.

    Author Email : hemmin@msn.com

    Journal article : Journal of Equine Veterinary Science 2013 Vol.33 No.2 pp.71-73 ref.16

    Abstract : Although the importance of coenzyme Q10 (CoQ10) in healthhealthSubject Category: Miscellaneous
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    and disease and its critical role in cellular bioenergeticsbioenergeticsSubject Category: Disciplines, Occupations and Industries
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    have been well established in various species, there is a total lack of information on the role of CoQ10 in horseshorsesSubject Category: Organism Names
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    . Therefore, the present study was undertaken first to ascertain the occurrence of CoQ10 and/or possibly other homologs of coenzyme Q (CoQ) in horse serum, and then to examine the response to CoQ10 supplementation on serum CoQ10 concentration. The study was carried out with 2-year-old ThoroughbredthoroughbredSubject Category: Organism Names
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    thoroughbredSubject Category: Animal Breeds
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    horses. Total CoQ (reduced and oxidized forms) in serum was assayed by high-performance liquid chromatographychromatographySubject Category: Techniques, Methodologies and Equipment
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    . The data show that horse serum contains CoQ as CoQ10, at a much lower concentration as compared with that of humans and several other species. There is no evidence for the presence of coenzyme Q9 or other homologs of CoQ. On supplementation with CoQ10 at 800 mg a day (1.47 mg/kg body weightbody weightSubject Category: Properties
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    ), there was a significant increase in serum CoQ10 concentration, approximately 2.7-fold at 60 days. CoQ10 supplementation at this dosage was found to be safe and well tolerated. Additional studies are needed to examine whether maintaining higher serum CoQ10 concentrations is of potential health benefit to the horses, as assessed by selected biochemical markersbiochemical markersSubject Category: Chemicals and Chemical Groups
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    and also in terms of performance.

    ISSN : 0737-0806

    DOI : 10.1016/j.jevs.2012.05.001

    Record Number : 20133110509

    Publisher : Elsevier

    Location of publication : New York

    Country of publication : USA

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : EquusequusSubject Category: Organism Names
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    , horseshorsesSubject Category: Organism Names
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    , manmanSubject Category: Organism Names
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    , thoroughbredthoroughbredSubject Category: Animal Breeds
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    Descriptor(s) : analytical methodsanalytical methodsSubject Category: Techniques, Methodologies and Equipment
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    , animal feedinganimal feedingSubject Category: Techniques, Methodologies and Equipment
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    , biochemical markersbiochemical markersSubject Category: Chemicals and Chemical Groups
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    , bioenergeticsbioenergeticsSubject Category: Disciplines, Occupations and Industries
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    , blood serumblood serumSubject Category: Anatomical and Morphological Structures
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    , body weightbody weightSubject Category: Properties
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    , chromatographychromatographySubject Category: Techniques, Methodologies and Equipment
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    , coenzymescoenzymesSubject Category: Chemicals and Chemical Groups
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    , healthhealthSubject Category: Miscellaneous
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    , markersmarkersSubject Category: Miscellaneous
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    , researchresearchSubject Category: Disciplines, Occupations and Industries
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    , supplementary feedingsupplementary feedingSubject Category: Miscellaneous
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    , ubiquinoneubiquinoneSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : analytical techniques, biomarkers, coenzyme q, homologues, mitoquinones, studies, ubiquinonesubiquinonesSubject Category: Chemicals and Chemical Groups
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    Broader term(s) : horseshorsesSubject Category: Organism Names
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    , EquusequusSubject Category: Organism Names
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    , EquidaeequidaeSubject Category: Organism Names
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    , PerissodactylaperissodactylaSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , HomohomoSubject Category: Organism Names
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    , HominidaehominidaeSubject Category: Organism Names
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    , primatesprimatesSubject Category: Organism Names
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