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Keterkaitan panhisterektomi dan suplemen 1,25- dihidroksivitamin D3 dengan risiko urolitiasis pada tikus.
Hartiningsih; Anggraeni, D.; Widiyono, I.; Wuryastuti, H.
Author Affiliation :
Bagian Ilmu Bedah dan Radiologi, Fakultas Kedokteran Hewan Universitas Gadjah Mada, Jln. Fauna 2 Kampus UGM, Yogyakarta, Indonesia.
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The objective of this research was to study the correlation of panhisterectomy and supplement 1.25- dihydroxyvitamin D3 on urolithiasis risk in Wistar rats. Twenty female Wistar rats at 8 weeks of age, were divided into four groups (control fed standard diet, control fed standard diet+1,25-dihydroxyvitamin D3 supplement, panhisterectomy fed standard diet and panhisterectomy fed standard diet +1,25-dihydroxyvitamin D3 supplement). Eleven weeks after treatment, each of rats was placed into individual metabolic cage for balance study for a week. From day 4 to 11 of the balance study, every morning the remaining food, feces, and urine were collected and recorded for calcium (Ca) analysis. At the end of balance study, blood samples were taken from canthus retroorbitalis medialis for estrogen analysis. The results showed urinary and fecal Ca excretions were not significantly different compared to the control group. Calcium consumption was significantly higher (P<0.05) in panhisterectomized rats compared with those in control rats. While, estrogen in panhisterectomized group was not significantly different to those in control rats. Calcium urinary and Ca consumption in rats consuming 1,25-dihydroxyvitamin D3 supplement were significantly higher (P<0.05) compared with those in without 1,25-dihydroxyvitamin D3 supplementation, but Ca excretion in feses was not significantly different. Estrogen in rats consuming 1.25-dihydroxyvitamin D3 supplement was significantly lower (P<0.05) compared with the rats that without 1,25-dihydroxyvitamin D3 supplemention. It can be concluded that panhisterectomy does not seem to affect urolithiasis risk, while 1,25-dihydroxyvitamin D3 supplement may affect urolithiasis risk. There is likely no association between panhisterectomy and 1.25-dihydroxyvitamin D3 supplementation on urolithiasis risk in Wistar rats.
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Redaksi Jurnal Veteriner
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Organism descriptor(s) :
blood chemistry, calcitriol, calcium, diets, excretion, faeces, feed intake, feed supplements, hysterectomy, oestrogens, rat feeding, risk assessment, risk factors, urine, urolithiasis
1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D, estrogens, feces
Broader term(s) :
Muridae, rodents, mammals, vertebrates, Chordata, animals, eukaryotes