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  • Molecular evolution of a polymorphic HSP40-like protein encoded in the histocompatibility locus of an invertebrate chordate.

    Author(s) : Nydam, M. L.Hoang, T. A.Shanley, K. M.Tomaso, A. W. de

    Author Affiliation : Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.

    Author Email : marie.nydam@centre.edudetomaso@lifesci.ucsb.edu

    Journal article : Developmental and Comparative Immunology 2013 Vol.41 No.2 pp.128-136 ref.many

    Abstract : Allorecognition, the ability to distinguish self from non-self, occurs in most organisms. Despite the ubiquity of the allorecognition process, the genetic basis for allorecognition remains unexplored in most taxa outside vertebrates and flowering plants. The allorecognition system in the colonial ascidian Botryllus schlosseribotryllus schlosseriSubject Category: Organism Names
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    is a notable exception. We have recently identified a polymorphic gene within the fuhc locus that may play a role in allorecognition. The encoded protein, called Hsp40-L, is a Type II member of the J-protein family which usually functions as a co-chaperone with Hsp70. While many of the residues that interact with Hsp70 are conserved in Hsp40-L, it may not be a housekeeping protein because it is surprisingly polymorphic and expressed in the ampullae, the site of allorecognition. While the majority of the Hsp40-L protein appears to evolve under purifying selection, a section of the C-terminal region likely experiences balancing/directional selection, characteristic of other allorecognition proteins.

    ISSN : 0145-305X

    DOI : 10.1016/j.dci.2013.03.004

    Record Number : 20133328443

    Publisher : Elsevier Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Botryllus schlosseribotryllus schlosseriSubject Category: Organism Names
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    Descriptor(s) : aquatic animalsaquatic animalsSubject Category: Organism Groups
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    , aquatic invertebratesaquatic invertebratesSubject Category: Organism Groups
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    , aquatic organismsaquatic organismsSubject Category: Organism Groups
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    , genesgenesSubject Category: Miscellaneous
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    , genetic polymorphismgenetic polymorphismSubject Category: Properties
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    , heat shock proteinsheat shock proteinsSubject Category: Chemicals and Chemical Groups
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    , locilociSubject Category: Miscellaneous
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    Identifier(s) : aquatic species

    Broader term(s) : BotryllusbotryllusSubject Category: Organism Names
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    , StyelidaestyelidaeSubject Category: Organism Names
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    , AscidiaceaascidiaceaSubject Category: Organism Names
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    , TunicatatunicataSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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