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  • Recurrent outbreaks of infectious bursal disease (IBD) in a layer farm caused by very virulent IBD virus (vvIBDV) in India: pathology and molecular analysis.

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    Author(s) : Barathidasan, R.Singh, S. D.Kumar, M. A.Desingu, P. A.Palanivelu, M.Singh, M.Dhama, K.

    Author Affiliation : Avian Diseases Section, Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly - 243 122, Uttar Pradesh, India.

    Author Email : kdhama@rediffmail.com

    Journal article : South Asian Journal of Experimental Biology 2013 Vol.3 No.4 pp.200-206 ref.28

    Abstract : The present study was carried out to investigate and characterize the nature of infectious bursal disease virusinfectious bursal disease virusSubject Category: Organism Names
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    (IBDV) involved in the recurrent outbreaksoutbreaksSubject Category: Miscellaneous
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    in an experimental layer farm in Bareilly, Uttar Pradeshuttar pradeshSubject Category: Geographic Entities
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    , IndiaindiaSubject Category: Geographic Entities
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    using direct tissue reverse transcription-polymerase chain reaction (RT-PCR) followed by nucleotide sequencing of VP2 gene. A total of three acute IBD outbreaks with the interval of 4-6 months were recorded in the batch of 3-5 weeks-old layer chicks in the year 2012-2013. Tissues collected from necropsied birdsbirdsSubject Category: Organism Names
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    were found RT-PCR positive for IBDV VP2 gene. Genetic analysis of the sequenced VP2 gene revealed the IBDV belonged to very virulent (vv) subtype and had amino acids at positions 222A, 256I, 294I, and 299S typical for vvIBDV strainsstrainsSubject Category: Organism Groups
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    isolated worldwide. It had only one unique amino acid change in the antigenic peak A (210-225 aa) at position 212D->N (Asp->Asn), which is not observed in any of the vvIBDVs isolated in India and abroad. Phylogenetic analysis revealed the isolates were more closely related to vvIBDV strains rA and rB (U.S.A.), Gx and HLJ-7 (China), OKYM (Japan), and shared >95% nucleotide homology with them. The VP2 gene shared 96.7% amino acid homology with IBDI+ vaccine strain used in India, comparatively higher among other vaccines strains, suggesting that IBD intermediate plus (IBDI+) vaccine might provide optimum cross protection, also for other vvIBDV strains. The vvIBDV strains remain a threat to poultrypoultrySubject Category: Organism Groups
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    industry worldwide, and require regular monitoring and genetic analysis in order to keep track of the appearance and evolution of antigenically different IBDV strains or subtypes.

    ISSN : 2230-9799

    URL : http://sajeb.org/.../8892

    Record Number : 20133403283

    Publisher : Infofacility

    Location of publication : Ghaziabad

    Country of publication : India

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : birdsbirdsSubject Category: Organism Names
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    , fowlsfowlsSubject Category: Organism Names
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    , Infectious bursal disease virusinfectious bursal disease virusSubject Category: Organism Names
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    Descriptor(s) : animal pathologyanimal pathologySubject Category: Disciplines, Occupations and Industries
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    , avian infectious bursitisavian infectious bursitisSubject Category: Diseases, Disorders, and Symptoms
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    , clinical aspectsclinical aspectsSubject Category: Miscellaneous
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    , genesgenesSubject Category: Miscellaneous
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    , henshensSubject Category: Organism Groups
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    , outbreaksoutbreaksSubject Category: Miscellaneous
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    , poultrypoultrySubject Category: Organism Groups
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    , relapserelapseSubject Category: Diseases, Disorders, and Symptoms
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    , reverse transcriptase PCRreverse transcriptase pcrSubject Category: Techniques, Methodologies and Equipment
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    , strainsstrainsSubject Category: Organism Groups
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    , virulencevirulenceSubject Category: Miscellaneous
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    Identifier(s) : chickens, clinical picture, domesticated birds, infectious bursal disease, recurrence of disease, relapses, reverse transcriptase polymerase chain reaction, RT-PCR

    Geographical Location(s) : IndiaindiaSubject Category: Geographic Entities
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    , Uttar Pradeshuttar pradeshSubject Category: Geographic Entities
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    Broader term(s) : Gallus gallusgallus gallusSubject Category: Organism Names
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    , GallusgallusSubject Category: Organism Names
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    , PhasianidaephasianidaeSubject Category: Organism Names
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    , GalliformesgalliformesSubject Category: Organism Names
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    , birdsbirdsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , AvibirnavirusavibirnavirusSubject Category: Organism Names
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    , BirnaviridaebirnaviridaeSubject Category: Organism Names
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    , dsRNA Virusesdsrna virusesSubject Category: Organism Names
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    , RNA Virusesrna virusesSubject Category: Organism Names
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    , virusesvirusesSubject Category: Organism Names
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    , Commonwealth of Nationscommonwealth of nationsSubject Category: Institutions and Organisations
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    , Developing Countriesdeveloping countriesSubject Category: Miscellaneous
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    , South Asiasouth asiaSubject Category: Geographic Entities
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    , AsiaasiaSubject Category: Geographic Entities
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    , IndiaindiaSubject Category: Geographic Entities
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