You are signed in as:
  • IFPRI
  • Signed in via:
  • IP Address

  • Choose a colour
  • Sedative and anesthetic activities of the essential oils of Hyptis mutabilis (Rich.) Briq. and their isolated components in silver catfish (Rhamdia quelen).

    Author(s) : Silva, L. L.Garlet, Q. I.Benovit, S. C.Dolci, G.Mallmann, C. A.Bürger, M. E.Baldisserotto, B.Longhi, S. J.Heinzmann, B. M.

    Author Affiliation : Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

    Author Email : berta.heinzmann@gmail.com

    Journal article : Brazilian Journal of Medical and Biological Research 2013 Vol.46 No.9 pp.771-779 ref.38

    Abstract : This study evaluated the sedative and anesthetic effects of the essential oilsessential oilsSubject Category: Commodities and Products
    see more details
    essential oilsSubject Category: Chemicals and Chemical Groups
    see more details
    (EO) of HyptishyptisSubject Category: Organism Names
    see more details
    mutabilis
    (Rich.) Briq. and their isolated components on silver catfish (Rhamdia quelenrhamdia quelenSubject Category: Organism Names
    see more details
    ). Quantitative chemical differences between the EOs obtained from leavesleavesSubject Category: Anatomical and Morphological Structures
    see more details
    and inflorescencesinflorescencesSubject Category: Anatomical and Morphological Structures
    see more details
    were verified, and a new chemotype rich in globulol was described. Although there were no significant differences in the time of induction for sedation and anesthesiaanesthesiaSubject Category: Miscellaneous
    see more details
    anesthesiaSubject Category: Miscellaneous
    see more details
    between the EOs, only the leaf EO at 344 mg/L anesthetized all fish without side effects. Fractionation of the leaf EO was carried out by column chromatography. The isolated compounds [(+)-1-terpinen-4-ol and (--)-globulol] showed different activity from that detected for the leaf EO in proportional concentrations and similar sedation to a eugenol control at 10 mg/L. However, fish exposed to 1-terpinen-4-ol (3 and 10 mg/L) did not remain sedated for 30 min. Anesthesia was obtained with 83-190 mg/L globulol, but animals showed loss of mucus during induction and mortality at these concentrations. SynergismsynergismSubject Category: Miscellaneous
    see more details
    of the depressor effects was detected with the association of globulol and benzodiazepine (BDZ), compared with either drug alone. Fish exposed to BDZ or globulol+BDZ association showed faster recovery from anesthesia in water containing flumazenil, but the same did not occur with globulol. In conclusion, the use of globulol in aquacultureaquacultureSubject Category: Disciplines, Occupations and Industries
    see more details
    procedures should be considered only at sedative concentrations of 10 and 20 mg/L, and its mechanism of action seems not to involve the GABAA-BDZ system.

    ISSN : 0100-879X

    DOI : 10.1590/1414-431X20133013

    Record Number : 20133415557

    Publisher : Associação Brasileira de Divulgação Cientifica

    Location of publication : Ribeirâo Preto

    Country of publication : Brazil

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : HyptishyptisSubject Category: Organism Names
    see more details
    , plantsplantsSubject Category: Organism Names
    see more details
    , Rhamdia quelenrhamdia quelenSubject Category: Organism Names
    see more details

    Descriptor(s) : anaesthesiaanaesthesiaSubject Category: Miscellaneous
    see more details
    , aquacultureaquacultureSubject Category: Disciplines, Occupations and Industries
    see more details
    , aquatic animalsaquatic animalsSubject Category: Organism Groups
    see more details
    , aquatic organismsaquatic organismsSubject Category: Organism Groups
    see more details
    , benzodiazepinesbenzodiazepinesSubject Category: Chemicals and Chemical Groups
    see more details
    , chemical compositionchemical compositionSubject Category: Properties
    see more details
    , chemotypeschemotypesSubject Category: Organism Groups
    see more details
    , essential oil plantsessential oil plantsSubject Category: Commodities and Products
    see more details
    , essential oilsessential oilsSubject Category: Chemicals and Chemical Groups
    see more details
    , gamma-aminobutyric acidgamma-aminobutyric acidSubject Category: Chemicals and Chemical Groups
    see more details
    , herb-drug interactionsherb-drug interactionsSubject Category: Miscellaneous
    see more details
    , inflorescencesinflorescencesSubject Category: Anatomical and Morphological Structures
    see more details
    , leavesleavesSubject Category: Anatomical and Morphological Structures
    see more details
    , neuroleptic propertiesneuroleptic propertiesSubject Category: Properties
    see more details
    , oil plantsoil plantsSubject Category: Commodities and Products
    see more details
    , plant compositionplant compositionSubject Category: Properties
    see more details
    , sedative propertiessedative propertiesSubject Category: Properties
    see more details
    , synergismsynergismSubject Category: Miscellaneous
    see more details

    Identifier(s) : anesthesiaanesthesiaSubject Category: Miscellaneous
    see more details
    , aquatic species, chemical constituents of plants, essential oil crops, GABA, Hyptis mutabilis, synergy

    Broader term(s) : LamiaceaelamiaceaeSubject Category: Organism Names
    see more details
    , LamialeslamialesSubject Category: Organism Names
    see more details
    , eudicotseudicotsSubject Category: Organism Names
    see more details
    , angiospermsangiospermsSubject Category: Organism Names
    see more details
    , SpermatophytaspermatophytaSubject Category: Organism Names
    see more details
    , plantsplantsSubject Category: Organism Names
    see more details
    , eukaryoteseukaryotesSubject Category: Organism Names
    see more details
    , RhamdiarhamdiaSubject Category: Organism Names
    see more details
    , PimelodidaepimelodidaeSubject Category: Organism Names
    see more details
    , SiluriformessiluriformesSubject Category: Organism Names
    see more details
    , OsteichthyesosteichthyesSubject Category: Organism Names
    see more details
    , fishesfishesSubject Category: Organism Names
    see more details
    , vertebratesvertebratesSubject Category: Organism Names
    see more details
    , ChordatachordataSubject Category: Organism Names
    see more details
    , animalsanimalsSubject Category: Organism Names
    see more details