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  • A study on antidiabetic activity of the leaf and stem of Alocasia indica L. in steptozotocin induced diabetic rats.

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    Author(s) : Karim, M. R.Nasrin FerdousNarayan RoySharma, S. C. D.Jahan, M. G. S.Shovon, M. S.

    Author Affiliation : Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh.

    Author Email : karim.robi@gmail.com

    Journal article : International Journal of Biosciences (IJB) 2014 Vol.5 No.6 pp.195-202 ref.20

    Abstract : Medical and clinical investigations of plants have been making tremendous contributions of life sciences, health and medicine. Medicinal plantsmedicinal plantsSubject Category: Organism Groups
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    medicinal plantsSubject Category: Commodities and Products
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    play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. The present study was aimed at evaluating the effect of Alocasia indica L on blood glucose level in normal and Streptozotocin-induced diabetic ratsratsSubject Category: Organism Names
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    with stress on evaluation of probable mechanism of antidiabetic action. In vivo, antiheperglycemic activity of Alocasia indica leavesleavesSubject Category: Anatomical and Morphological Structures
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    and stem extract showed activity against Steptozotocin induced diabetic rats. Diabetes was induced by single intraperitoneal injection of Streptozotocin (60 mg/kg) and doses of test extracts 200 and 400 mg/kg were studied in Streptozotocin induced diabetic rats for the period of 21 days. Glibenclamide 10 mg/kg was used as standard drug. There was a significant increase in blood glucose level in diabetic rats when compared with normal control due to streptozotocin injection. In this study, daily oral administration of the leaves and stem extracts for the period of 21 days led to a dose dependent fall in blood glucose levels and showed significant (P<0.05) reduction in blood glucose levels compared to diabetic control group at dose 200 and 400 mg/kg. The test extracts also showed significant (P<0.05) weight gain of diabetic rats compared with the control group at the same dose. The present study reported that Alocasia indica L. may be very useful for the improvement of the complications of diabetes.

    ISSN : 2220-6655

    URL : http://www.innspub.net/wp-content/upl...

    Record Number : 20143359260

    Publisher : Shamokal Publications

    Location of publication : Dhaka

    Country of publication : Bangladesh

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Alocasia macrorrhizosalocasia macrorrhizosSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    , ratsratsSubject Category: Organism Names
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    Descriptor(s) : blood sugarblood sugarSubject Category: Chemicals and Chemical Groups
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    , body weightbody weightSubject Category: Properties
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    , experimental diabetesexperimental diabetesSubject Category: Diseases, Disorders, and Symptoms
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    , hypoglycaemic propertieshypoglycaemic propertiesSubject Category: Properties
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    , leavesleavesSubject Category: Anatomical and Morphological Structures
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    , medicinal plantsmedicinal plantsSubject Category: Commodities and Products
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    , pharmacologypharmacologySubject Category: Disciplines, Occupations and Industries
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    , stemsstemsSubject Category: Anatomical and Morphological Structures
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    Identifier(s) : anti-diabetic properties, anti-hyperglycaemic properties, antidiabetic properties, antihyperglycaemic properties, blood glucose, drug plants, glucose in blood, hypoglycemic propertieshypoglycemic propertiesSubject Category: Properties
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    , medicinal herbs, officinal plants

    Broader term(s) : AlocasiaalocasiaSubject Category: Organism Names
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    , AraceaearaceaeSubject Category: Organism Names
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    , AlismatalesalismatalesSubject Category: Organism Names
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    , monocotyledonsmonocotyledonsSubject Category: Organism Names
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    , angiospermsangiospermsSubject Category: Organism Names
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    , SpermatophytaspermatophytaSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , MuridaemuridaeSubject Category: Organism Names
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    , rodentsrodentsSubject Category: Organism Names
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    , mammalsmammalsSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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