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  • Pathological lesions and inducible nitric oxide synthase expressions in the liver of mice experimentally infected with Clonorchis sinensis.

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    Author(s) : Yang QingLiShen JiQingXue YanCheng XiaoBingJiang ZhiHuaYang YiChaoChen YingDanZhou XiaoNong

    Author Affiliation : National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

    Author Email : ipdzhouxn@sh163.net

    Journal article : Korean Journal of Parasitology 2015 Vol.53 No.6 pp.777-783 ref.38

    Abstract : The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.

    ISSN : 0023-4001

    DOI : 10.3347/kjp.2015.53.6.777

    URL : http://parasitol.kr/upload/pdf/kjp-53...

    Record Number : 20163020407

    Publisher : Korean Society for Parasitology and Tropical Medicine

    Location of publication : Seoul

    Country of publication : Korea Republic

    Language of text : English

    Language of summary : English

    Indexing terms for this abstract:

    Organism descriptor(s) : Clonorchis, Clonorchis sinensis, mice, Trematoda

    Descriptor(s) : clonorchiasis, disease models, experimental infection, helminthoses, helminths, human diseases, infections, laboratory animals, liver, necrosis, nitric oxide, parasites, parasitoses, pathology, trematode infections

    Identifier(s) : experimental transmission, fluke infections, parasitic diseases, parasitic infestations, parasitic worms, parasitosis

    Broader term(s) : Opisthorchiidae, Digenea (Trematoda), Trematoda, Platyhelminthes, invertebrates, animals, eukaryotes, Clonorchis, Muridae, rodents, mammals, vertebrates, Chordata