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  • Thermodynamic driving force of hydrogen on rumen microbial metabolism: a theoretical investigation.

    Author(s) : Lingen, H. J. vanPlugge, C. M.Fadel, J. G.Kebreab, E.Bannink, A.Dijkstra, J.

    Author Affiliation : TI Food and Nutrition, Wageningen, Netherlands.

    Author Email : henk.vanlingen@wur.nl

    Journal article : PLoS ONE 2016 Vol.11 No.10 pp.e0161362 ref.60

    Abstract : Hydrogen is a key product of rumen fermentationrumen fermentationSubject Category: Miscellaneous
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    and has been suggested to thermodynamically controlcontrolSubject Category: Miscellaneous
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    the production of the various volatile fatty acidsvolatile fatty acidsSubject Category: Chemicals and Chemical Groups
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    (VFA). Previous studies, however, have not accounted for the fact that only thermodynamic near-equilibrium conditions control the magnitude of reaction rate. Furthermore, the role of NAD, which is affected by hydrogen partial pressure (PH2), has often not been considered. The aim of this study was to quantify the control of PH2 on reaction rates of specific fermentation pathways, methanogenesis and NADHnadhSubject Category: Chemicals and Chemical Groups
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    oxidation in rumen microbes. The control of PH2 was quantified using the thermodynamic potential factor (FT), which is a dimensionless factor that corrects a predicted kinetic reaction rate for the thermodynamic control exerted. Unity FT was calculated for all glucose fermentation pathways considered, indicating no inhibitioninhibitionSubject Category: Miscellaneous
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    of PH2 on the production of a specific type of VFA (e.g., acetate, propionate and butyrate) in the rumen. For NADH oxidation without ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity to zero for different NAD+ to NADH ratiosratiosSubject Category: Properties
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    and pH of 6.2 and 7.0, which indicates thermodynamic control of PH2. For NADH oxidation with ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity at pH of 7.0 only. For the acetate to propionate conversion, FT increased from 0.65 to unity with increasing PH2, which indicates thermodynamic control. For propionate to acetate and butyrate to acetate conversions, FT decreased to zero below the rumen range of PH2, indicating full thermodynamic suppression. For methanogenesis by archaeaarchaeaSubject Category: Organism Names
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    without cytochromes, FT differed from unity only below the rumen range of PH2, indicating no thermodynamic control. This theoretical investigation shows that thermodynamic control of PH2 on individual VFA produced and associated yield of hydrogen and methane cannot be explained without considering NADH oxidation.

    ISSN : 1932-6203

    DOI : 10.1371/journal.pone.0161362

    Record Number : 20173001985

    Publisher : Public Library of Sciences (PLoS)

    Location of publication : San Francisco

    Country of publication : USA

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : ArchaeaarchaeaSubject Category: Organism Names
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    Descriptor(s) : butyratesbutyratesSubject Category: Chemicals and Chemical Groups
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    , coenzymescoenzymesSubject Category: Chemicals and Chemical Groups
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    , controlcontrolSubject Category: Miscellaneous
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    , fatty acidsfatty acidsSubject Category: Chemicals and Chemical Groups
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    , fermentationfermentationSubject Category: Techniques, Methodologies and Equipment
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    , inhibitioninhibitionSubject Category: Miscellaneous
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    , methanemethaneSubject Category: Chemicals and Chemical Groups
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    , methane productionmethane productionSubject Category: Miscellaneous
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    , microbial floramicrobial floraSubject Category: Organism Groups
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    , microorganismsmicroorganismsSubject Category: Organism Groups
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    , NADHnadhSubject Category: Chemicals and Chemical Groups
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    , physiologyphysiologySubject Category: Disciplines, Occupations and Industries
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    , productionproductionSubject Category: Miscellaneous
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    , ratiosratiosSubject Category: Properties
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    , researchresearchSubject Category: Disciplines, Occupations and Industries
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    , rumenrumenSubject Category: Anatomical and Morphological Structures
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    , rumen digestionrumen digestionSubject Category: Natural Processes
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    , rumen fermentationrumen fermentationSubject Category: Miscellaneous
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    , rumen florarumen floraSubject Category: Organism Groups
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    , rumen microorganismsrumen microorganismsSubject Category: Organism Groups
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    , volatile fatty acidsvolatile fatty acidsSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : digestion in rumen, micro-organisms, microflora, nicotinamide adenine dinucleotide (reduced), rumen micro-organisms, studies

    Broader term(s) : prokaryotesprokaryotesSubject Category: Organism Names
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