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Primarizky, H.; Yuniarti, W. M.; Lukiswanto, B. S.
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Department of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
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Aim: The occurrence of acute renal failure (ARF) cases continues to increase every year. Some of the cases are due to nephrotoxic effect caused by overdose of antibiotic consumption or abuse of the drug, gentamicin. An antibiotic therapy that can be used to overcome in such a case is the pomegranate extracts. However, until now, studies using pomegranate for cases of ARF have not been done. This study aims to determine changes in body weight, the levels of total protein (TP), and the levels of serum uric acid (UA) as a result of the pomegranate extract consumption. Materials and Methods: A total number of 32 rats (Rattus norvegicus) were divided into four groups randomly. One group was assigned as the control group (P0) and given intraperitoneal (i.p.) saline and 0.3% carboxy methyl cellulose sodium (CMC) Na; P1 was provided with 80 mg/kg bw/i.p. gentamicin and 0.3% CMC Na orally, P2 was supplied with 80 mg/kg bw/i.p. gentamicin and ellagic acid in 0.3% CMC Na, and P3 was given 80 mg/kg bw/i.p. gentamicin and 150 mg/kg bw pomegranate extract in 0.3% CMC Na. The provision of treatment was carried out in 8 days and followed by making the overthrow of body weight and blood sampling for the examination of study variables. Results: The results taken by doing the analysis of variance method for the four treatment groups show that the control group (P0) has significant differences from P1, P2, and P3 (p<0.05), but there are no significant differences among the other three treatment groups. Meanwhile, the average values of serum UA levels among P1, P2, and P3 indicate significant differences. Conclusion: In conclusion, the administration of pomegranate extracts in the treatment of nephrotoxicity toward rats is effective to maintain normal body weight, normal TP levels, and the UA blood serum of the rats. As this study is a preventive therapy, it needs further research about the effective dose as a curative therapy, its level of effectiveness and its long-term side effects.
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Organism descriptor(s) :
plants, Punica granatum, rats, Rattus norvegicus
animal models, body weight, fruits, medicinal plants, non-wood forest products, plant extracts, pomegranates, proteins, renal failure, uric acid
brown rat, drug plants, kidney failure, medicinal herbs, minor forest products, non-timber forest products, Norway rat, officinal plants
Broader term(s) :
Punica, Lythraceae, Myrtales, eudicots, angiosperms, Spermatophyta, plants, eukaryotes, Muridae, rodents, mammals, vertebrates, Chordata, animals, Rattus, Murinae