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  • Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression.

    Author(s) : Wang YaoTeng MiaoMiaoWang DeZhenYan JinMiao JiYanZhou ZhiQiangZhu WenTao

    Author Affiliation : Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.

    Author Email : wentaozhu@cau.edu.cn

    Journal article : Environmental Pollution 2017 Vol.229 pp.264-271

    Abstract : Although epoxiconazoleepoxiconazoleSubject Category: Chemicals and Chemical Groups
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    is the worldwidely used fungicide, limited information is known about its toxic effectseffectsSubject Category: Properties
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    and bioaccumulationbioaccumulationSubject Category: Miscellaneous
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    behavior in freshwater ecosystemsecosystemsSubject Category: Habitats
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    . In this study, zebrafish were exposed to epoxiconazole at concentrations of 100 and 1000 µg L- for 21 d. 1H NMR-based metabolomicsmetabolomicsSubject Category: Miscellaneous
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    analysis showed that low- and high-dose epoxiconazole exposure resulted in two similar but not identical patterns for the change of endogenous metabolitesmetabolitesSubject Category: Chemicals and Chemical Groups
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    related to energy, lipid and amino acid metabolism. The expression of genesgenesSubject Category: Miscellaneous
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    associated with mitochondrial respiratory chain, ATPatpSubject Category: Chemicals and Chemical Groups
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    synthesis and fatty acid β-oxidation were further measured to explore the reason for the disturbed energy metabolismenergy metabolismSubject Category: Natural Processes
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    , finding epoxiconazole had an inhibitioninhibitionSubject Category: Miscellaneous
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    effect on the genes expression of the above ways. Significant enantioselectivity was observed with (+)-epoxiconazole enrichment in the bioaccumulation process. These results will be of great importance in understanding the toxic effects induced by epoxiconazole and provide important basis for its comprehensive environmental assessmentenvironmental assessmentSubject Category: Techniques, Methodologies and Equipment
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    .

    ISSN : 0269-7491

    DOI : 10.1016/j.envpol.2017.05.087

    Record Number : 20173349886

    Publisher : Elsevier Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : DaniodanioSubject Category: Organism Names
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    , Danio reriodanio rerioSubject Category: Organism Names
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    Descriptor(s) : aquatic animalsaquatic animalsSubject Category: Organism Groups
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    , aquatic environmentaquatic environmentSubject Category: Habitats
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    , aquatic organismsaquatic organismsSubject Category: Organism Groups
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    , ATPatpSubject Category: Chemicals and Chemical Groups
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    , bioaccumulationbioaccumulationSubject Category: Miscellaneous
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    , ecosystemsecosystemsSubject Category: Habitats
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    , effectseffectsSubject Category: Properties
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    , energy metabolismenergy metabolismSubject Category: Natural Processes
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    , environmental assessmentenvironmental assessmentSubject Category: Techniques, Methodologies and Equipment
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    , epoxiconazoleepoxiconazoleSubject Category: Chemicals and Chemical Groups
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    , fatty acidsfatty acidsSubject Category: Chemicals and Chemical Groups
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    , fresh waterfresh waterSubject Category: Miscellaneous
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    , freshwater ecologyfreshwater ecologySubject Category: Miscellaneous
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    , functional genomicsfunctional genomicsSubject Category: Miscellaneous
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    , fungicidesfungicidesSubject Category: Chemicals and Chemical Groups
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    , gene expressiongene expressionSubject Category: Miscellaneous
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    , genesgenesSubject Category: Miscellaneous
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    , inhibitioninhibitionSubject Category: Miscellaneous
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    , metabolismmetabolismSubject Category: Natural Processes
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    , metabolitesmetabolitesSubject Category: Chemicals and Chemical Groups
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    , metabolomicsmetabolomicsSubject Category: Miscellaneous
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    , mitochondriamitochondriaSubject Category: Anatomical and Morphological Structures
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    , pesticidespesticidesSubject Category: Chemicals and Chemical Groups
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    , pollutionpollutionSubject Category: Miscellaneous
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    , toxicitytoxicitySubject Category: Properties
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    Identifier(s) : adenosine triphosphate, aquatic species, environmental pollution, freshwater biology, fungistats

    Broader term(s) : CyprinidaecyprinidaeSubject Category: Organism Names
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    , CypriniformescypriniformesSubject Category: Organism Names
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    , OsteichthyesosteichthyesSubject Category: Organism Names
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    , fishesfishesSubject Category: Organism Names
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    , vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , DaniodanioSubject Category: Organism Names
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