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  • Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure.

    Author(s) : Liang XueFangZha JinMiaoMartyniuk, C. J.Wang ZiJianZhao Ji

    Author Affiliation : School of Ecology and Environment, Inner Mongolia University, Hohhot 010021, China.

    Author Email : liangxf@imu.edu.cn

    Journal article : Environmental Pollution 2017 Vol.229 pp.459-469

    Abstract : Benzotriazole (BT) and its associated derivativesderivativesSubject Category: Chemicals and Chemical Groups
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    are used ubiquitously in industrial processes, and can be detected in indoor temperature coolants and in chemicals designed to inhibit corrosioncorrosionSubject Category: Natural Processes
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    . This chemical has been widely detected in aquatic environments and shows some degree of environmental persistencepersistenceSubject Category: Properties
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    . Evidence has shown that BT exposureexposureSubject Category: Miscellaneous
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    can negatively affect endocrine systems and can result in neurotoxicity in fish. However, no study has examined whether this chemical exhibits hepatotoxicity in fish, and if so, what are the underlying mechanism associated with the damage. To address this knowledge gap, we measured the liverliverSubject Category: Anatomical and Morphological Structures
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    proteome of adult male Chinese rare minnow (Gobiocypris rarus) exposed to either 0.05, 0.5, or 5 mg/L BT for 28 days. Overall, 17 proteinsproteinsSubject Category: Chemicals and Chemical Groups
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    were induced and 9 were reduced in abundance following BT treatment (ratio >1.5, p<0.05). Pathway analysisanalysisSubject Category: Techniques, Methodologies and Equipment
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    revealed that cellular processes affected by BT included xenobiotic clearance, oxidative stressoxidative stressSubject Category: Miscellaneous
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    response, apoptosisapoptosisSubject Category: Natural Processes
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    , and translationtranslationSubject Category: Miscellaneous
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    . Moreover, transcripts related to these toxic pathways were also significantly affected by BT. In addition, rare minnows exposed to BT showed signs of hypertrophy of hepatocytes, nucleinucleiSubject Category: Anatomical and Morphological Structures
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    pyknosis, and higher levels of cellular vacuolization compared to the controls, thus these early proteomic responses in the liver may be related to pathology (i.e. adverse outcome pathway). Our data demonstrate that BT dysregulates molecular responses in the liver and tissue pathology indicative of damage. This study provides new insight into BT hepatotoxicity in Chinese rare minnow.

    ISSN : 0269-7491

    DOI : 10.1016/j.envpol.2017.06.013

    Record Number : 20173349907

    Publisher : Elsevier Ltd

    Location of publication : Oxford

    Country of publication : UK

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : fishesfishesSubject Category: Organism Names
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    Descriptor(s) : analysisanalysisSubject Category: Techniques, Methodologies and Equipment
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    , apoptosisapoptosisSubject Category: Natural Processes
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    , aquatic animalsaquatic animalsSubject Category: Organism Groups
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    , aquatic environmentaquatic environmentSubject Category: Habitats
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    , aquatic organismsaquatic organismsSubject Category: Organism Groups
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    , corrosioncorrosionSubject Category: Natural Processes
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    , derivativesderivativesSubject Category: Chemicals and Chemical Groups
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    , exposureexposureSubject Category: Miscellaneous
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    , hepatotoxinshepatotoxinsSubject Category: Chemicals and Chemical Groups
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    , liverliverSubject Category: Anatomical and Morphological Structures
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    , nucleinucleiSubject Category: Anatomical and Morphological Structures
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    , oxidative stressoxidative stressSubject Category: Miscellaneous
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    , persistencepersistenceSubject Category: Properties
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    , pollutionpollutionSubject Category: Miscellaneous
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    , proteinsproteinsSubject Category: Chemicals and Chemical Groups
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    , stressstressSubject Category: Miscellaneous
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    , toxicitytoxicitySubject Category: Properties
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    , translationtranslationSubject Category: Miscellaneous
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    , xenobioticsxenobioticsSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : aquatic species, cell nuclei, environmental pollution, RNA translation

    Broader term(s) : vertebratesvertebratesSubject Category: Organism Names
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    , ChordatachordataSubject Category: Organism Names
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    , animalsanimalsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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