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  • Constituents from Nauclea latifolia with anti-Haemophilus influenzae type b inhibitory activities.

    Author(s) : Bankeu, J. J. K.Kagho, D. U. K.Fongang, Y. S. F.Toghueo, R. M. K.Mba'ning, B. M.Feuya, G. R. T.Fekam, F. B.Tchouankeu, J. C.Ngouela, S. A.Sewald, N.Lenta, B. N.Ali, M. S.

    Author Affiliation : Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon.

    Author Email : bk_jeanjules@yahoo.fr/bankeu@gmail.com

    Journal article : Journal of Natural Products 2019 Vol.82 No.9 pp.2580-2585 ref.3

    Abstract : Three previously undescribed indole alkaloidsindole alkaloidsSubject Category: Chemicals and Chemical Groups
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    , named latifolianine A (1) and latifoliaindoles A and B (2 and 3), along with 10 known compounds (4-13), were isolated from the heartwoodheartwoodSubject Category: Anatomical and Morphological Structures
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    of Nauclea latifolianauclea latifoliaSubject Category: Organism Names
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    . Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A (1) represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety. Plausible biogenetic routes toward latifolianine A (1) and latifoliaindoles A and B (2 and 3) were proposed. All the isolates were assessed in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    for their inhibitory effectseffectsSubject Category: Properties
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    on Haemophilus influenzaehaemophilus influenzaeSubject Category: Organism Names
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    . Naucleidinal (7) exhibited potent antibacterial activity (MIC value of 3.1 μg/mL) as compared to a reference drug, ciprofloxacinciprofloxacinSubject Category: Chemicals and Chemical Groups
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    (MIC value of 1.6 μg/mL).

    ISSN : 0163-3864

    DOI : 10.1021/acs.jnatprod.9b00463

    Record Number : 20219943807

    Publisher : American Chemical Society

    Location of publication : Washington

    Country of publication : USA

    Language of text : English

    Indexing terms for this abstract:

    Organism descriptor(s) : HaemophilushaemophilusSubject Category: Organism Names
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    , Haemophilus influenzaehaemophilus influenzaeSubject Category: Organism Names
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    , NaucleanaucleaSubject Category: Organism Names
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    , Nauclea latifolianauclea latifoliaSubject Category: Organism Names
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    Descriptor(s) : alkaloidsalkaloidsSubject Category: Chemicals and Chemical Groups
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    , antibacterial propertiesantibacterial propertiesSubject Category: Properties
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    , antibioticsantibioticsSubject Category: Chemicals and Chemical Groups
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    , chemical compositionchemical compositionSubject Category: Properties
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    , ciprofloxacinciprofloxacinSubject Category: Chemicals and Chemical Groups
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    , constituentsconstituentsSubject Category: Properties
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    , effectseffectsSubject Category: Properties
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    , extractsextractsSubject Category: Miscellaneous
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    , heartwoodheartwoodSubject Category: Anatomical and Morphological Structures
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    , in vitroin vitroSubject Category: Techniques, Methodologies and Equipment
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    , indole alkaloidsindole alkaloidsSubject Category: Chemicals and Chemical Groups
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    , inhibitioninhibitionSubject Category: Miscellaneous
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    , isolationisolationSubject Category: Techniques, Methodologies and Equipment
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    , monoterpenesmonoterpenesSubject Category: Chemicals and Chemical Groups
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    , monoterpenoidsmonoterpenoidsSubject Category: Chemicals and Chemical Groups
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    , pathogenspathogensSubject Category: Organism Groups
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    , phytochemicalsphytochemicalsSubject Category: Chemicals and Chemical Groups
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    , terpenoidsterpenoidsSubject Category: Chemicals and Chemical Groups
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    , triterpenoidstriterpenoidsSubject Category: Chemicals and Chemical Groups
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    , fluoroquinolone antibioticsfluoroquinolone antibioticsSubject Category: Chemicals and Chemical Groups
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    Identifier(s) : bactericidal properties, terpenes

    Broader term(s) : PasteurellaceaepasteurellaceaeSubject Category: Organism Names
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    , PasteurellalespasteurellalesSubject Category: Organism Names
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    , GammaproteobacteriagammaproteobacteriaSubject Category: Organism Names
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    , ProteobacteriaproteobacteriaSubject Category: Organism Names
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    , BacteriabacteriaSubject Category: Organism Names
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    , prokaryotesprokaryotesSubject Category: Organism Names
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    , HaemophilushaemophilusSubject Category: Organism Names
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    , RubiaceaerubiaceaeSubject Category: Organism Names
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    , GentianalesgentianalesSubject Category: Organism Names
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    , eudicotseudicotsSubject Category: Organism Names
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    , angiospermsangiospermsSubject Category: Organism Names
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    , SpermatophytaspermatophytaSubject Category: Organism Names
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    , plantsplantsSubject Category: Organism Names
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    , eukaryoteseukaryotesSubject Category: Organism Names
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    , NaucleanaucleaSubject Category: Organism Names
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